Phase I Safety and Pharmacokinetic Study of CT-011, a Humanized Antibody Interacting with PD-1, in Patients with Advanced Hematologic Malignancies
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- Type
- article
- Published
- 2008-05-15
- Cited by
- 689
- References
- 17
- Access
- Open access
- OpenAlex
- https://openalex.org/W2021588881
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:603812
Keywords
Pharmacokinetics, Medicine, Cmax, Antibody, Population
References
- A monoclonal antibody against a human B lymphoblastoid cell line induces tumor regression in mice.
- B7-H1 pathway and its role in the evasion of tumor immunity
- Interaction between B7-H1 and PD-1 determines initiation and reversal of T-cell anergy.
- A lymphocyte-activating monoclonal antibody induces regression of human tumors in severe combined immunodeficient mice.
- Activation of human lymphocytes by a monoclonal antibody to B lymphoblastoid cells; molecular mass and distribution of binding protein
- B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function.
- Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
- Contribution of the PD-L1/PD-1 pathway to T-cell exhaustion: an update on implications for chronic infections and tumor evasion
- Role of PD-1 and its ligand, B7-H1, in early fate decisions of CD8 T cells.
- Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade
- Co-inhibitory molecules of the B7–CD28 family in the control of T-cell immunity
- PD-L2 is a second ligand for PD-1 and inhibits T cell activation
- Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation
- Expression of the B7-related molecule B7-H1 by glioma cells: a potential mechanism of immune paralysis.
- Expression of the B7 - related molecule B7 - H1 by glioma cells: a potential mechanism of immune paralysis
Cited by
- Estudio del rol de la vía de PD-1 sobre la respuesta inmune de células Nk y de los mecanismos inmunológicos inducidos por las células Th9 frente a la infección por M. tuberculosis
- Immunobiology of cancer therapies targeting CD137 and B7-H1/PD-1 cosignal pathways.
- Immunomodulating antibodies and drugs for the treatment of hematological malignancies
- The targeting of immunosuppressive mechanisms in hematological malignancies
- A Mini-Review for Cancer Immunotherapy: Molecular Understanding of PD-1/PD-L1 Pathway & Translational Blockade of Immune Checkpoints
- PD-1 and its ligands are important immune checkpoints in cancer
- Preliminary results of immune modulating antibody MDV9300 (pidilizumab) treatment in children with diffuse intrinsic pontine glioma
- PD-1 /PD-L1 checkpoint in hematological malignancies.
- Oncolytic immunotherapy and bortezomib synergy improves survival of refractory multiple myeloma in a preclinical model.
- Cancer immunotherapy targeting T cell costimulatory molecules
- Lenalidomide targets the T-cell co-stimulatory pathway to mediate immune modulation
- Programmed death-1 inhibition in renal cell carcinoma: clinical insights and future directions.
- [Immune-checkpoints: the new anti-cancer immunotherapies].
- Tumor dormancy: long-term survival in a hostile environment.
- Blockade of the B7-H1/PD-1 Pathway for Cancer Immunotherapy
- Overcoming Melanoma Immune Tolerance: Non-specific CTLA-4 Blockade/Interferon-alfa and Antigen Specific Immunization with TLR-9 Stimulation/Local GM-CSF as Components of a Melanoma Immunotherapeutic Strategy and Associated Biomarkers of Therapeutic Benefit
- Myeloid-Derived Suppressor Cells and Other Immune Escape Mechanisms in Chronic Leukemia
- Novel Immunologic Approaches in Lymphoma: Unleashing the Brakes on the Immune System
- Effect of Chronic Thoracic Spinal Cord Injury (SCI) on the Peripheral Immune System in Mice
- Caractérisation moléculaire et fonctionnelle des lymphocytes T CD8+/CD103+ infiltrant les tumeurs pulmonaires humaines
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