Bioconjugation by copper(I)-catalyzed azide-alkyne [3 + 2] cycloaddition.
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Summary
The copper-catalyzed cycloaddition reaction between azides and alkynes functions efficiently in aqueous solution in the presence of a tris(triazolyl)amine ligand to make rapid and reliable covalent connections to micromolar concentrations of protein decorated with either of the reactive moieties.
- Type
- article
- Published
- 2003-02-22
- Cited by
- 1,451
- References
- 0
- OpenAlex
- https://openalex.org/W2021320094
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:1654177
Keywords
Chemistry, Bioconjugation, Cycloaddition, Azide, Alkyne
References
Cited by
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