Stimulation of bone formation in vitro and in rodents by statins.
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Summary
It is shown that the statins, drugs widely used for lowering serum cholesterol, also enhance new bone formation in vitro and in rodents, and may have therapeutic applications for the treatment of osteoporosis.
- Type
- article
- Published
- 1999-12-03
- Cited by
- 1,831
- References
- 19
- OpenAlex
- https://openalex.org/W2020364703
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:44869135
Keywords
Lovastatin, Osteoporosis, Simvastatin, Calvaria, Cancellous bone
References
- Actions of recombinant interleukin 1, interleukin 2, and interferon-gamma on bone resorption in vitro.
- Infusions of recombinant human interleukins 1 alpha and 1 beta cause hypercalcemia in normal mice.
- Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro.
- Lovastatin-mediated G1 arrest is through inhibition of the proteasome, independent of hydroxymethyl glutaryl-CoA reductase.
- Bone Morphogenetic Protein 2 (BMP-2) Enhances BMP-3, BMP-4, and Bone Cell Differentiation Marker Gene Expression During the Induction of Mineralized Bone Matrix Formation in Culturesof Fetal Rat Calvarial Osteoblasts
- Hypotensive activity of fibroblast growth factor.
- Perspectives: How many women have osteoporosis now?
- Effects of transforming growth factor β on bone nodule formation and expression of bone morphogenetic protein 2, osteocalcin, osteopontin, alkaline phosphatase, and type I collagen mRNA in long‐term cultures of fetal rat calvarial osteoblasts
- In vivo effects of human recombinant transforming growth factor β on bone turnover in normal mice
- Nitrogen‐Containing Bisphosphonates Inhibit the Mevalonate Pathway and Prevent Post‐Translational Prenylation of GTP‐Binding Proteins, Including Ras
- Bisphosphonates induce apoptosis in mouse macrophage‐like cells in vitro by a nitric oxide‐independent mechanism
- Effects of a synthetic peptide of a parathyroid hormone-related protein on calcium homeostasis, renal tubular calcium reabsorption, and bone metabolism in vivo and in vitro in rodents.
- By how much and how quickly does reduction in serum cholesterol concentration lower risk of ischaemic heart disease?
- Immortalized murine osteoblasts derived from BMP 2-T-antigen expressing transgenic mice.
- 5-Lipoxygenase metabolites inhibit bone formation in vitro.
- Effects of interleukin-1 on bone turnover in normal mice.
- The value of lowering cholesterol after myocardial infarction.
- Structure-activity relationships of new heterocycle-containing bisphosphonates as inhibitors of bone resorption and as inhibitors of growth of Dictyostelium discoideum amoebae.
Cited by
- The Molecular Genetics of Bone Formation
- Effect of atorvastatin on bone mineral density in patients with acute coronary syndrome.
- Neuroprotection mediated by changes in the endothelial actin cytoskeleton.
- Bone anabolic effects of statins
- Targeting Rho in cardiovascular disease.
- Statin Given Perorally to Adult Rats Increases Cancellous Bone Mass and Compressive Strength
- Ein Vergleich der antiresorptiven Effekte von Bisphosphonaten und Statinen auf Polyethylenpartikel-induzierte Osteolysen / A Comparison of the Antiresorptive Effects of Bisphosphonates and Statins on Polyethylene Particle-Induced Osteolysis
- Effects of simvastatin on bone regeneration in the mandibles of ovariectomized rats and on blood cholesterol levels.
- Effect of simvastatin treatment on bone mineral density and bone turnover in hypercholesterolemic postmenopausal women: a 1-year longitudinal study.
- Hesperidin, a citrus flavonoid, inhibits bone loss and decreases serum and hepatic lipids in ovariectomized mice.
- Endothelins in bone cancer metastases.
- Effects of Egg Yolk Proteins on the Longitudinal Bone Growth of Adolescent Male Rats
- FSH directly regulates bone mass.
- Fluvastatin does not elevate periosteal osteogenesis induce by Moloney sarcoma virus (MSV) in mice.
- The effect of statins in colorectal cancer is mediated through the bone morphogenetic protein pathway.
- In vivo performance of absorbable collagen sponges with rosuvastatin in critical-size cortical bone defects.
- Synergistic Effect of Statins and Postmenopausal Hormone Therapy in the Prevention of Skeletal Fractures in Elderly Women
- Simvastatin application to augment facial jaw bone in a dog model: pilot study.
- Simvastatin prevents the induction of interleukin-6 gene expression by titanium particles in human osteoblastic cells.
- The statin-iron nexus: anti-inflammatory intervention for arterial disease prevention.
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