In vivo effects of human recombinant transforming growth factor β on bone turnover in normal mice
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Summary
Data show that TGF‐β has powerful effects on local bone cell function in vivo and that these effects may be mediated, in part, by prostaglandin generation.
- Type
- article
- Published
- 1990-10-01
- Cited by
- 230
- References
- 30
- Access
- Open access
- OpenAlex
- https://openalex.org/W2084134989
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:39124459
Keywords
In vivo, Osteoclast, Endocrinology, Internal medicine, Prostaglandin E2
References
- Cartilage-inducing factor-A. Apparent identity to transforming growth factor-beta.
- Skeletal tissue and transforming growth factor β
- Transforming growth factor beta is a bifunctional regulator of replication and collagen synthesis in osteoblast-enriched cell cultures from fetal rat bone.
- Growth factors and the regulation of bone remodeling.
- Infusions of recombinant human interleukins 1 alpha and 1 beta cause hypercalcemia in normal mice.
- Human platelet-derived transforming growth factor-beta stimulates parameters of bone growth in fetal rat calvariae.
- Cortical hyperostosis following long-term administration of prostaglandin E1 in infants with cyanotic congenital heart disease.
- Transforming growth factor beta inhibits formation of osteoclast-like cells in long-term human marrow cultures.
- Stimulation of bone formation by prostaglandin E2.
- Fundamental and Clinical Bone Physiology
- In vivo stimulation of bone formation by transforming growth factor-beta.
- Alpha and beta human transforming growth factors stimulate prostaglandin production and bone resorption in cultured mouse calvaria.
- Transforming growth factor beta inhibits bone resorption in fetal rat long bone cultures.
- Modulation of type beta transforming growth factor activity in bone cultures by osteotropic hormones.
- Some recent advances in the chemistry and biology of transforming growth factor-beta
- Osteoblasts synthesize and respond to transforming growth factor-type beta (TGF-beta) in vitro
- Effects of a synthetic peptide of a parathyroid hormone-related protein on calcium homeostasis, renal tubular calcium reabsorption, and bone metabolism in vivo and in vitro in rodents.
- Effects of interleukin-1 on bone turnover in normal mice.
- Transforming Growth Factor‐β1 Is Expressed and Synthesized during Fracture Healing
- Production of lymphotoxin, a bone-resorbing cytokine, by cultured human myeloma cells.
Cited by
- Control of TGF-beta receptor expression in bone.
- Stability, characterization, formulation, and delivery system development for transforming growth factor-beta 1.
- Development of the osteoblast phenotype: molecular mechanisms mediating osteoblast growth and differentiation.
- Fisiología del tejido óseo
- Cytokine regulation of bone cell differentiation.
- Growth Regulatory Factors and Bone
- Serum IGF-1 and IGFBP-3 Levels in Middle Aged Turkish Males: Relationships with Bone Mineral Density and Markers of Bone Turnover (Male Osteoporosis & IGF-1, IGFBP-3)
- A model of myelofibrosis and osteosclerosis in mice induced by overexpressing thrombopoietin (mpl ligand): reversal of disease by bone marrow transplantation.
- Skeletal growth factors.
- Phosphatidylserine-Containing Liposomes Inhibit the Differentiation of Osteoclasts and Trabecular Bone Loss
- Cellular and molecular alterations of osteoblasts in human disorders of bone formation.
- The Role of Adjuvant Therapy with Bisphosphonates in Cancer
- Human amniotic tumor that induces new bone formation in vivo produces growth-regulatory activity in vitro for osteoblasts identified as an extended form of basic fibroblast growth factor.
- Regulation of the expression of the type‐II collagen gene in periosteum‐derived cells by three members of the transforming growth factor–β superfamily
- The restoration of skeletal mass: a theoretic overview.
- The influence of transforming growth factor β1 on mesenchymal cell repair of full‐thickness cartilage defects
- Regulation of collagen type I and biglycan mRNA levels by hormones and growth factors in normal and immortalized osteoblastic cell lines
- Transforming growth factor β1-induced cellular heterogeneity in the periosteum of rat parietal bones
- Stimulation of Bone Formation In Vivo by Insulin-Like Growth Factor-II in Rats
- Human Periosteum Is a Source of Cells for Orthopaedic Tissue Engineering: A Pilot Study
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