Biochemistry of nitric oxide and its redox-activated forms.
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Summary
The integration of this chemistry with current perspectives of NO biology illuminates many aspects of NO biochemistry, including the enzymatic mechanism of synthesis, the mode of transport and targeting in biological systems, the means by which its toxicity is mitigated, and the function-regulating interaction with target proteins.
- Type
- review
- Published
- 1992-12-18
- Cited by
- 2,706
- References
- 68
- OpenAlex
- https://openalex.org/W2019814232
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:12608620
Keywords
Nitric oxide, Nitroxyl, Chemistry, Redox, Chemical biology
References
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- Peroxynitrite oxidation of sulfhydryls. The cytotoxic potential of superoxide and nitric oxide.
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- Structural effects in alkyl nitrite oxidation of human hemoglobin.
- Trapping of nitric oxide produced during denitrification by extracellular hemoglobin.
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- Generation of EPR-detectable nitrosyl-iron complexes in tumor target cells cocultured with activated macrophages.
- Constitutive and inducible nitric oxide synthases incorporate molecular oxygen into both nitric oxide and citrulline.
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- Mechanisms of Nitrogen Dioxide Reactions: Initiation of Lipid Peroxidation and the Production of Nitrous Acid
- Formation of N-nitroso compounds: chemistry, kinetics, and in vivo occurrence.
- Reversible conversion of nitroxyl anion to nitric oxide by superoxide dismutase.
- Catalysis of nitrosyl transfer by denitrifying bacteria is facilitated by nitric oxide.
- DNA deaminating ability and genotoxicity of nitric oxide and its progenitors.
- Oxidation of dithiothreitol during turnover of nitric oxide reductase: evidence for generation of nitroxyl with the enzyme from Paracoccus denitrificans.
- Nitric oxide. A novel signal transduction mechanism for transcellular communication.
Cited by
- Calcium transients in brain ischemia: role in neuronal injury.
- Validation of a simple method assessing nitric oxide and nitrogen dioxide concentrations
- Clinical relevance of defects in signalling pathways.
- Regulation of Gene Expression by Nitric Oxide
- Towards an understanding of the role of glutamate in neurodegenerative disorders: energy metabolism and neuropathology
- Termination of endothelin signaling: Role of nitric oxide
- Stress (heat shock) proteins: molecular chaperones in cardiovascular biology and disease.
- Role of nitric oxide in cellular iron metabolism
- N-Methyl-d-aspartate Induces Neurogranin/RC3 Oxidation in Rat Brain Slices*
- Comparison of the roles of reactive oxygen and nitrogen intermediates in the host response to Mycobacterium tuberculosis using transgenic mice.
- Higher level of plasma nitric oxide in spontaneously hypertensive rats.
- Dynamic state of S-nitrosothiols in human plasma and whole blood.
- Nitric Oxide Modulates Fracture Healing
- Airway nitrogen oxide measurements in asthma and other pediatric respiratory diseases.
- Nitric oxide increases fluid extravasation from the splenic circulation of the rat.
- Role of nitric oxide in carcinogenesis and tumour progression.
- Lipoic acid and vitamin C potentiate nitric oxide synthesis in human aortic endothelial cells independently of cellular glutathione status
- Naftidrofuryl-driven regulation of endothelial ICAM-1 involves nitric oxide.
- Protection from noise-induced lipid peroxidation and hair cell loss in the cochlea.
- N-Acetyl-cysteine modulates inducible nitric oxide synthase gene expression in human hepatocytes.
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