Role of nitric oxide in cellular iron metabolism
Explore this paper's citation graph
Summary
The results suggest that NO+-mediated degradation of IRP2 plays a major role in iron metabolism during inflammation.
- Type
- review
- Published
- 2003-03-01
- Cited by
- 50
- References
- 74
- OpenAlex
- https://openalex.org/W9840034
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:31781527
Keywords
RNA-binding protein, Transferrin receptor, Ferritin, Untranslated region, Chemistry
References
- Iron-dependent oxidation, ubiquitination, and degradation of iron regulatory protein 2: implications for degradation of oxidized proteins.
- Physiology and pathophysiology of nitric oxide.
- Translational regulation via iron‐responsive elements by the nitric oxide/NO‐synthase pathway.
- Function and regulation of transferrin and ferritin.
- Requirements for iron‐regulated degradation of the RNA binding protein, iron regulatory protein 2.
- Identification of a novel iron‐responsive element in murine and human erythroid delta‐aminolevulinic acid synthase mRNA.
- S-nitrosylation: spectrum and specificity
- Iron regulates cytoplasmic levels of a novel iron-responsive element-binding protein without aconitase activity.
- Characterization and evolution of the expressed rat ferritin light subunit gene and its pseudogene family. Conservation of sequences within noncoding regions of ferritin genes.
- Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice
- Characterization of a second RNA-binding protein in rodents with specificity for iron-responsive elements.
- Mutational analysis of the [4Fe‐4S]‐cluster converting iron regulatory factor from its RNA‐binding form to cytoplasmic aconitase.
- Nitric oxide synthase structure and mechanism.
- Rapid responses to oxidative stress mediated by iron regulatory protein.
- Modification of a free Fe-S cluster cysteine residue in the active iron-responsive element-binding protein prevents RNA binding.
- EPR characterization of molecular targets for NO in mammalian cells and organelles
- Role of free radicals and catalytic metal ions in human disease: an overview.
- Biosynthesis of nitric oxide activates iron regulatory factor in macrophages.
- Nitric oxide: physiology, pathophysiology, and pharmacology.
- Differentiation of murine macrophages to express nonspecific cytotoxicity for tumor cells results in L-arginine-dependent inhibition of mitochondrial iron-sulfur enzymes in the macrophage effector cells.
Cited by
- Parallels and contrasts between iron and copper metabolism
- The iron cycle and oxidative stress in the lung.
- The hemochromatosis C282Y allele: a risk factor for hepatic veno-occlusive disease after hematopoietic stem cell transplantation
- Radicals for life : the various forms of nitric oxide
- Elucidating the Role of Ferritin in the Iron Metabolic Pathway of Aedes aegypti
- Chloroquine as a therapeutic option for mild post malaria anaemia
- Dietary factors influencing non-heme iron absorption
- Statin‐induced inhibition of breast cancer proliferation and invasion involves attenuation of iron transport: intermediacy of nitric oxide and antioxidant defence mechanisms
- Free radicals act as effectors in the growth inhibition and apoptosis of iron-treated Burkitt's lymphoma cells
- Oxalomalate affects the inducible nitric oxide synthase expression and activity.
- Nitric Oxide Does Not Contribute to Inflammation-Induced Hypoferremia in Humans
- Genomic screening and complications of hematopoietic stem cell transplantation: has the time come?
- Effects of sham air and cigarette smoke on A549 lung cells: implications for iron-mediated oxidative damage.
- Secreted ferritin: mosquito defense against iron overload?
- Reactions of the NO redox forms NO+, •NO and HNO (protonated NO–) with the melatonin metabolite N1‐acetyl‐5‐methoxykynuramine
- Iron delocalisation in the pathogenesis of malarial anaemia.
- An Iron-induced Nitric Oxide Burst Precedes Ubiquitin-dependent Protein Degradation for Arabidopsis AtFer1 Ferritin Gene Expression*
- Increased Expression of Hypothalamic NADPH–Diaphorase Neurons in Mice with Iron Supplement
- Role of transcription factor Sp1 and RNA binding protein HuR in the down-regulation of Dr+ Escherichia coli receptor protein Decay Accelerating Factor (DAF or CD55) by Nitric oxide
- Receptors for Transferrin on Human Neutrophils
Related papers
- Species specificity of iron delivery in hybridomas
- Commentary: mutations of transferrin receptor 2 (Trf-2) and iron storage disease.
- Lymphocyte proliferation is controlled by both iron availability and regulation of iron uptake pathways.
- Receptor assay with radiolabeled transferrin.
- Transferrin receptor 2: a new molecule in iron metabolism.
- Effect of aluminium on iron uptake and transferrin-receptor expression by human erythroleukaemia K562 cells.
- Transferrin receptor 2 mediates uptake of transferrin-bound and non-transferrin-bound iron.
- The role of transferrin receptors and iron delivery in mouse embryonic morphogenesis.
- Transferrin/Transferrin Receptor-Mediated Drug Delivery