A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage.
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Summary
The evidence presented strongly supports a role for the gamma-H2AX and the PI-3 protein kinase family in focus formation at sites of double-strand breaks and suggests the possibility of a change in chromatin structure accompanying double-Strand break repair.
- Type
- article
- Published
- 2000-08-01
- Cited by
- 2,256
- References
- 62
- Access
- Open access
- OpenAlex
- https://openalex.org/W2019405732
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:16108315
Keywords
RAD51, DNA damage, Biology, Wortmannin, DNA repair
References
- Regulation of RAD53 by the ATM-Like Kinases MEC1 and TEL1 in Yeast Cell Cycle Checkpoint Pathways
- S phase specific formation of the human Rad51 protein nuclear foci in lymphocytes.
- Radiosensitization of human tumor cells by the phosphatidylinositol3-kinase inhibitors wortmannin and LY294002 correlates with inhibition of DNA-dependent protein kinase and prolonged G2-M delay.
- The phosphatidylinositol 3-kinase inhibitor wortmannin sensitizes murine fibroblasts and human tumor cells to radiation and blocks induction of p53 following DNA damage.
- Mutations in XRS2 and RAD50 delay but do not prevent mating-type switching in Saccharomyces cerevisiae
- Repair of endonuclease-induced double-strand breaks in Saccharomyces cerevisiae: essential role for genes associated with nonhomologous end-joining.
- Use of an immobilized enzyme and specific antibodies to analyse the accessibility and role of histone tails in chromatin structure.
- When is a lipid kinase not a lipid kinase? When it is a protein kinase.
- DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product.
- Nuclear foci of mammalian recombination proteins are located at single-stranded DNA regions formed after DNA damage.
- ATM-related genes: what do they tell us about functions of the human gene?
- DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139*
- Nuclear foci of mammalian Rad51 recombination protein in somatic cells after DNA damage and its localization in synaptonemal complexes.
- Saturation of a DNA repair process in dividing and nondividing mammalian cells.
- Nuclease Activities in a Complex of Human Recombination and DNA Repair Factors Rad50, Mre11, and p95*
- Telomere maintenance is dependent on activities required for end repair of double-strand breaks.
- Localization and dynamic relocalization of mammalian Rad52 during the cell cycle and in response to DNA damage.
- Initial events in the cellular effects of ionizing radiations: clustered damage in DNA.
- TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1.
- Alteration of telomeric sequences and senescence caused by mutations in RAD50 of Saccharomyces cerevisiae
Cited by
- Cytometric Analysis of DNA Damage: Phosphorylation of Histone H2AX as a Marker of DNA Double-Strand Breaks (DSBs)
- Threonine 68 of Chk2 Is Phosphorylated at Sites of DNA Strand Breaks*
- Campylobacter jejuni Cytolethal Distending Toxin Promotes DNA Repair Responses in Normal Human Cells
- A new system for laser‐UVA‐microirradiation of living cells
- MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways
- Role of tumor suppressors in DNA damage response.
- Characterization of Histone H2A.X Expression in Testis and Specific Labeling of Germ Cells at the Commitment Stage of Meiosis with Histone H2A.X Promoter-Enhanced Green Fluorescent Protein Transgene1
- Molecular targets and mechanisms in formation of chromosomal aberrations: contributions of Soviet scientists
- Control of Radiosensitivity of F9 Mouse Teratocarcinoma Cells by Regulation of Histone H2AX Gene Expression using a Tetracycline Turn-Off System
- In search of drug treatment for genetic defects in the DNA damage response: the example of ataxia-telangiectasia.
- ATR-dependent radiation-induced γH2AX foci in bystander primary human astrocytes and glioma cells
- Bystander response in human lymphoblastoid TK6 cells.
- The dendritic polymer DAB-Am16 as a novel tumoricidal compound
- Role of inflammatory cytokines and DNA damage repair proteins in sulfur mustard exposed mice liver
- Characteristic 8 keV X Rays Possess Radiobiological Properties of Higher-LET Radiation
- The Pan-Deacetylase Inhibitor Panobinostat Inhibits Growth of Hepatocellular Carcinoma Models by Alternative Pathways of Apoptosis
- Autophosphorylation and ATM Activation
- BMI1 Is Recruited to DNA Breaks and Contributes to DNA Damage-Induced H2A Ubiquitination and Repair
- A small molecule Inauhzin inhibits SIRT1 activity and suppresses tumour growth through activation of p53
- Extensive podocyte loss triggers a rapid parietal epithelial cell response.
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