Autophosphorylation and ATM Activation
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Summary
This work targeted the ATM phosphorylation sites, Ser367 and Ser2996, for further study by generating phosphospecific antibodies against these sites and demonstrated thatosphorylation of both was rapidly induced by radiation, providing further support for the importance of autophosphorylated in the activation and function of ATM in vivo.
- Type
- article
- Published
- 2010-12-13
- Cited by
- 129
- References
- 78
- Access
- Open access
- OpenAlex
- https://openalex.org/W21149446
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25785015
Keywords
Intellect, Object (grammar), Transcendental number, Epistemology, Philosophy
References
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- ATM stabilizes DNA double-strand-break complexes during V(D)J recombination
- Phosphorylation of ATM by Cdk5 mediates DNA damage signaling and regulates neuronal death
- Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells
- Dimethyl multiplexed labeling combined with microcolumn separation and MS analysis for time course study in proteomics
- Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
- Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair
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- High resolution visual mapping of stretched DNA by fluorescent hybridization
- Solving the RIDDLE of 53BP1 recruitment to sites of damage
- ATM associates with and phosphorylates p53: mapping the region of interaction
- Mdc1 couples DNA double‐strand break recognition by Nbs1 with its H2AX‐dependent chromatin retention
- Tyrosine Dephosphorylation of H2AX Modulates Apoptosis and Survival Decisions
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- Neutral Phosphate-Affinity SDS-PAGE system for profiling of protein phosphorylation.
- Stress-induced Premature Promotes Prostate Cancer Growth and Metastasis through Alteration of Microenvironment
- Role of Histone Metabolism and Chromatin Structure in DNA Repair
- Localisation et fonction de CHK2 en mitose
- Interactions between mitochondria and inflammatory factors during cellular senescence
- A theoretical investigation of protein recruitment during the DNA damage response and of the dynamics of DNA replication
- Structure and Assembly of the PI3K-like Protein Kinases (PIKKs) Revealed by Electron Microscopy
- Targeting ataxia-telangiectasia mutated deficient malignancies with poly ADP ribose polymerase inhibitors
- ATM protein kinase: the linchpin of cellular defenses to stress
- ATM: awakening the guardian angel or drugging the -absolute tailor master- -
- Pharmacological inhibition of ATM by KU55933 stimulates ATM transcription
- Development of a High-Content High-Throughput Screening Assay for the Discovery of ATM Signaling Inhibitors
- Importance of PIKKs in NF-κB activation by genotoxic stress.
- The ATM signaling network in development and disease
- Chemotherapy induced DNA damage response
- ATM-mediated Snail Serine 100 phosphorylation regulates cellular radiosensitivity.
- Involvement of DNA Damage Response Pathways in Hepatocellular Carcinoma
- Analysis of Mutations That Dissociate G2 and Essential S Phase Functions of Human Ataxia Telangiectasia-mutated and Rad3-related (ATR) Protein Kinase*
- Interplays between ATM/Tel1 and ATR/Mec1 in sensing and signaling DNA double-strand breaks.