Pharmacokinetics of [14C]Ciclesonide After Oral and Intravenous Administration to Healthy Subjects
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Summary
Because of an almost complete first-pass metabolism, ciclesonide is undetectable in serum after oral administration, and any cicleonide swallowed after oral inhalation does not contribute to systemically available cicles onide or to its active metabolite.
- Type
- article
- Published
- 2004-01-01
- Cited by
- 104
- References
- 19
- OpenAlex
- https://openalex.org/W2019259561
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24190574
Keywords
Ciclesonide, Pharmacokinetics, Bioavailability, Oral administration, Medicine
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- Asthma
Cited by
- Ciclesonide Disposition and Metabolism: Pharmacokinetics, Metabolism, and Excretion in the Mouse, Rat, Rabbit, and Dog
- Ciclesonide for the treatment of asthma
- ciclesonide in the Management of Asthma
- Ciclesonide in persistent asthma: the evidence of its therapeutic value
- Inhaled Corticosteroids in Children with Asthma
- Inhaled ciclesonide versus inhaled budesonide or inhaled beclomethasone or inhaled fluticasone for chronic asthma in adults: a systematic review
- Similar Results in Children with Asthma for Steady State Pharmacokinetic Parameters of Ciclesonide Inhaled with or without Spacer
- How the Lung Handles Drugs
- Cortisol suppression as a surrogate marker for inhaled corticosteroid-induced growth retardation in children.
- Inhaled corticosteroids for asthma: are they all the same?
- Determination of Absolute Bioavailability of Rifampicin by Varying the Mode of Intravenous Administration and the Time of Sampling
- Preclinical Profile of Ciclesonide, a Novel Corticosteroid for the Treatment of Asthma
- The systemic safety of inhaled corticosteroid therapy: a focus on ciclesonide.
- Formation of fatty acid conjugates of ciclesonide active metabolite in the rat lung after 4-week inhalation of ciclesonide.
- Ciclesonide and the treatment of asthma
- Ciclesonide: a safe and effective inhaled corticosteroid for the treatment of asthma
- Model-Based Covariate Pharmacokinetic Analysis and Lack of Cortisol Suppression by the New Inhaled Corticosteroid Ciclesonide Using a Novel Cortisol Release Model
- Pharmacokinetics of ciclesonide and desisobutyryl ciclesonide after administration via aqueous nasal spray or hydrofluoroalkane nasal aerosol compared with orally inhaled ciclesonide: an open-label, single-dose, three-period crossover study in healthy volunteers.
- Lower oropharyngeal deposition of inhaled ciclesonide via hydrofluoroalkane metered-dose inhaler compared with budesonide via chlorofluorocarbon metered-dose inhaler in healthy subjects
- Equivalent Pharmacokinetics of the Active Metabolite of Ciclesonide With and Without Use of the AeroChamber Plus™ Spacer for Inhalation
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