Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles
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Summary
Evidence is provided of inducing an RNAi mechanism of action in a human from the delivered siRNA and the presence of an mRNA fragment that demonstrates that siRNA-mediated mRNA cleavage occurs specifically at the site predicted for anRNAi mechanism from a patient who received the highest dose of the nanoparticles.
- Type
- article
- Published
- 2010-03-21
- Cited by
- 2,436
- References
- 30
- Access
- Open access
- OpenAlex
- https://openalex.org/W2014509855
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4310744
Keywords
RNA interference, Small interfering RNA, RNA, Ribonucleotide reductase, Messenger RNA
References
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- Pharmacokinetics and tumor dynamics of the nanoparticle IT-101 from PET imaging and tumor histological measurements
Cited by
- Cell-specific siRNA delivery by peptides and antibodies.
- siRNAのDDS：シクロデキストリン/デンドリマー結合体
- The Emerging Therapeutic Role of RNA Interference in Disorders of the Central Nervous System
- Aberrant Expression of TfR1/CD71 in Thyroid Carcinomas Identifies a Novel Potential Diagnostic Marker and Therapeutic Target
- Recent progress in the therapeutic applications of nanotechnology
- Nanomedicine in cancer therapy: Innovative trends and prospects
- Special delivery: targeted therapy with small RNAs
- Modelling transport of layered double hydroxide nanoparticles in axons and dendrites of cortical neurons
- Surface-modified silica nanoparticles for tumor-targeted delivery of camptothecin and its biological evaluation.
- Targeting MYC-Regulated miRNAs to Combat Cancer.
- Amphiphilic dynamic NDI and PDI probes: imaging microdomains in giant unilamellar vesicles.
- Fluorescent Magnetic Nanoparticles for Magnetically Enhanced Cancer Imaging and Targeting in Living Subjects
- Targeting receptor-mediated endocytotic pathways with nanoparticles: rationale and advances
- Click-modified cyclodextrins as nonviral vectors for neuronal siRNA delivery.
- Bridge over troubled waters: understanding the synthetic and biological identities of engineered nanomaterials.
- A pH-responsive cyclodextrin-based hybrid nanosystem as a nonviral vector for gene delivery.
- Transcytosis and brain uptake of transferrin-containing nanoparticles by tuning avidity to transferrin receptor
- Tunable Delivery of siRNA from a Biodegradable Scaffold to Promote Angiogenesis In Vivo
- Zwitterionic-coated "stealth" nanoparticles for biomedical applications: recent advances in countering biomolecular corona formation and uptake by the mononuclear phagocyte system.
- Enhancing endosomal escape for nanoparticle mediated siRNA delivery.
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