Regulation of angiogenesis by hypoxia: role of the HIF system
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Summary
The role of HIF in developmental, adaptive and neoplastic angiogenesis, and the implications of oncogenic activation of extensive, physiologically interconnected hypoxia pathways for the tumor phenotype are discussed.
- Type
- review
- Published
- 2003-05-30
- Cited by
- 2,539
- References
- 122
- OpenAlex
- https://openalex.org/W2013818100
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:205379370
Keywords
Angiogenesis, Regulator, Hypoxia (environmental), Hypoxia-inducible factors, Biology
References
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- Coronary artery anomalies
- Vascular targeting therapy: potential benefit depends on tumor and host related effects.
- Measuring tumour vascular response to antivascular and antiangiogenic drugs.
- Influence of endurance exercise and diet on human placental development and fetal growth.
- Protein posttranslational modifications: the chemistry of proteome diversifications.
- Targeting hypoxia and angiogenesis through HIF-1alpha inhibition
- Hypoxia-regulated differentiation: let's step it up a Notch.
- Cellular and Molecular Dynamics in the Foreign Body Reaction
- Lack of Association between −460 C/T and 936 C/T of the Vascular Endothelial Growth Factor and Angiopoietin-2 Exon 4 G/A Polymorphisms and Ovarian, Cervical, and Endometrial Cancers
- Kallikrein-binding protein suppresses growth of hepatocellular carcinoma by anti-angiogenic activity.
- Correlative Imaging of Hypoxia and Angiogenesis in Oncology
- Vascular Endothelial Growth Factor Receptor-1 Regulates Postnatal Angiogenesis Through Inhibition of the Excessive Activation of Akt
- The head of Bartonella adhesin A is crucial for host cell interaction of Bartonella henselae
- Novel concepts in atherogenesis: angiogenesis and hypoxia in atherosclerosis
- Hypoxia-inducible factor-1α and -2α are expressed in most rectal cancers but only hypoxia-inducible factor-1α is associated with prognosis
- Cell-specific and hypoxia-dependent regulation of human HIF-3α: inhibition of the expression of HIF target genes in vascular cells
- The role of psychologic stress-induced hypoxia-inducible factor-1α in rat experimental periodontitis.
- EPO improves the proliferation and inhibits apoptosis of trophoblast and decidual stromal cells through activating STAT-5 and inactivating p38 signal in human early pregnancy.
- Co-culture of Retinal and Endothelial Cells Results in the Modulation of Genes Critical to Retinal Neovascularization
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