Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth.
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Summary
It is demonstrated that loss of murine Vhl is sufficient not only to stabilize Hif-alpha subunits under normoxia, but also fully activate HIF-mediated responses, having implications for the hierarchy of signaling events leading to HIF stabilization, nuclear translocation, and target gene expression.
- Type
- article
- Published
- 2003-01-01
- Cited by
- 173
- References
- 68
- Access
- Open access
- OpenAlex
- https://openalex.org/W1978583875
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:27529232
Keywords
Cell biology, Primary (astronomy), Cancer research, Cell growth, Biology
References
- Pten is essential for embryonic development and tumour suppression
- Suppression of tumor growth through disruption of hypoxia-inducible transcription
- von Hippel-Lindau protein promotes the assembly of actin and vinculin and inhibits cell motility.
- Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
- The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
- Regulation of Hypoxia-Inducible mRNAs by the von Hippel-Lindau Tumor Suppressor Protein Requires Binding to Complexes Containing Elongins B/C and Cul2
- The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity.
- Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit*
- Mechanism of regulation of the hypoxia‐inducible factor‐1α by the von Hippel‐Lindau tumor suppressor protein
- Asparagine Hydroxylation of the HIF Transactivation Domain: A Hypoxic Switch
- An essential role for p300/CBP in the cellular response to hypoxia.
- Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein.
- Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT
- The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins.
- Molecular cloning of the von Hippel-Lindau tumor suppressor gene and its role in renal carcinoma.
- Tumour suppression by the human von Hippel-Lindau gene product
- Hypoxia-induced Transcriptional Activation and Increased mRNA Stability of Vascular Endothelial Growth Factor in C6 Glioma Cells (*)
- Chronic effect of fatty acids on insulin release is not through the alteration of glucose metabolism in a pancreatic beta-cell line (βHC9)
- Up-regulation of hypoxia-inducible factors HIF-1α and HIF-2α under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function
- Transactivation and Inhibitory Domains of Hypoxia-inducible Factor 1α
Cited by
- Differential Regulation of the Transcriptional Activities of Hypoxia-Inducible Factor 1 Alpha (HIF-1α) and HIF-2α in Stem Cells
- Current understanding of the molecular mechanisms of kidney cancer: a primer for urologists.
- Review: Targeted therapy in renal cancer
- Regulators of angiogenesis in diabetes and tumors
- Pathology of the Nervous System in Von Hippel-Lindau Disease
- Functional analysis of the von Hippel-Lindau tumour suppressor in mice
- The hypoxia-inducible factor and tumor progression along the angiogenic pathway.
- Regulation of angiogenesis by hypoxia and hypoxia-inducible factors.
- Transcriptional Regulation by Hypoxia-Inducible Factors in Tumor Cells
- Functional analysis of the von Hippel-Lindau tumour suppressor and its role in tumourigenesis
- Transcription Association of VHL and SDH Mutations Link Hypoxia and Oxidoreductase Signals in Pheochromocytomas
- Cancer's sweet tooth.
- E2-EPF UCP targets pVHL for degradation and associates with tumor growth and metastasis
- Evolution of VHL tumourigenesis in nerve root tissue
- Identification of the KAI1 metastasis suppressor gene as a hypoxia target gene.
- Genetic evidence for a tumor suppressor role of HIF-2alpha.
- Multitasking by pVHL in tumour suppression.
- Role and mechanism of hypoxia-inducible factor-1 in cell growth and apoptosis of breast cancer cell line MDA-MB-231.
- Nervous system involvement in von Hippel–Lindau disease: pathology and mechanisms
- HIF-1 or HIF-2 induction is sufficient to achieve cell cycle arrest in NIH3T3 mouse fibroblasts independent from hypoxia
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