Mutations in hemG Mediate Resistance to Salicylidene Acylhydrazides, Demonstrating a Novel Link between Protoporphyrinogen Oxidase (HemG) and Chlamydia trachomatis Infectivity
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Summary
It is found that the iron-saturated SAH INP0341 (IS-INP 0341) specifically affects C. trachomatis infectivity with reduced generation of infectious elementary body (EB) progeny.
- Type
- article
- Published
- 2013-07-12
- Cited by
- 34
- References
- 61
- Access
- Open access
- OpenAlex
- https://openalex.org/W2013799812
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:12999110
Keywords
Biology, Protoporphyrinogen oxidase, Infectivity, Chlamydia trachomatis, Chlamydiaceae
References
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- Response of Chlamydia trachomatis serovar E to iron restriction in vitro and evidence for iron-regulated chlamydial proteins
- Salicylidene acylhydrazide-mediated inhibition of type III secretion system-1 in Salmonella enterica serovar Typhimurium is associated with iron restriction and can be reversed by free iron.
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- Actin Recruitment to the Chlamydia Inclusion Is Spatiotemporally Regulated by a Mechanism That Requires Host and Bacterial Factors
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- The biochemistry of heme biosynthesis.
- Protein delivery into eukaryotic cells by type III secretion machines
- Crystal Structure of Protoporphyrinogen Oxidase from Myxococcus Xanthus and its Complex with the Inhibitor Acifluorfen
- Heme biosynthesis is coupled to electron transport chains for energy generation
- Resolution of Holliday junctions in vitro requires the Escherichia coli ruvC gene product.
- A small-molecule inhibitor of type III secretion inhibits different stages of the infectious cycle of Chlamydia trachomatis
Cited by
- The Chlamydia trachomatis type III secretion substrates CT142, CT143, and CT144 are secreted into the lumen of the inclusion
- GrgA as a potential target of selective antichlamydials
- Design, synthesis and evaluation of novel polypharmacological antichlamydial agents.
- Application of β-Lactamase Reporter Fusions as an Indicator of Effector Protein Secretion during Infections with the Obligate Intracellular Pathogen Chlamydia trachomatis
- Chlamydia trachomatis In Vivo to In Vitro Transition Reveals Mechanisms of Phase Variation and Down-Regulation of Virulence Factors
- Expansion of the Chlamydia trachomatis inclusion does not require bacterial replication.
- Whole-genome enrichment and sequencing of Chlamydia trachomatisdirectly from clinical samples
- The Type III Secretion System (T3SS) of Chlamydophila psittaci Is Involved in the Host Inflammatory Response by Activating the JNK/ERK Signaling Pathway
- N-Acylated Derivatives of Sulfamethoxazole and Sulfafurazole Inhibit Intracellular Growth of Chlamydia trachomatis
- Identification of in vivo-induced bacterial protein antigens during calf infection with Chlamydia psittaci.
- Targeting the type III secretion system to treat bacterial infections
- The Bacterial Type III Secretion System as a Target for Developing New Antibiotics
- A 2-Pyridone-Amide Inhibitor Targets the Glucose Metabolism Pathway of Chlamydia trachomatis
- Benzylidene Acylhydrazides Inhibit Chlamydial Growth in a Type III Secretion- and Iron Chelation-Independent Manner
- Influence of chelation strength and bacterial uptake of gallium salicylidene acylhydrazide on biofilm formation and virulence of Pseudomonas aeruginosa.
- Approaches targeting the type III secretion system to treat or prevent bacterial infections
- New Frontiers in Type III Secretion Biology: the Chlamydia Perspective
- Evolutionary dynamics of Chlamydia trachomatis genome and identification of molecular patterns of hypothetical protein coding genes
- Salicylidene Acylhydrazides and Hydroxyquinolines Act as Inhibitors of Type Three Secretion Systems in Pseudomonas aeruginosa by Distinct Mechanisms
- N-Acylated Derivatives of Sulfamethoxazole Block Chlamydia Fatty Acid Synthesis and Interact with FabF
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