Salicylidene acylhydrazide-mediated inhibition of type III secretion system-1 in Salmonella enterica serovar Typhimurium is associated with iron restriction and can be reversed by free iron.

Keywords

Salmonella enterica, Salmonella, Secretion, Microbiology, Biology

References

• SopE, a secreted protein of Salmonelladublin, is translocated into the target eukaryotic cell via a sip‐dependent mechanism and promotes bacterial entryMiquel Monràs, Lluïsa Ortega, Sílvia Mondón — 1996
• Adaptation to the host environment: regulation of the SPI1 type III secretion system in Salmonella enterica serovar Typhimurium.Jules Taylor-Pickard — 2007
• Design issues for cDNA microarray experimentsYee Hwa Yang, Terry Speed — 2002
• Genetic and environmental control of salmonella invasion.Craig Altier — 2005
• HilD, HilC and RtsA constitute a feed forward loop that controls expression of the SPI1 type three secretion system regulator hilA in Salmonella enterica serovar TyphimuriumCraig D. Ellermeier, Jeremy R. Ellermeier, James M. Slauch — 2005
• Targeting bacterial virulence: inhibitors of type III secretion in Yersinia.Anna M. Kauppi, Roland Nordfelth, Hanna Uvell — 2003
• Identification of host‐specific colonization factors of Salmonella enterica serovar TyphimuriumEirwen Morgan, June Campbell, Sonya Rowe — 2004
• Delineation of the Salmonella enterica Serovar Typhimurium HilA Regulon through Genome-Wide Location and Transcript AnalysisInge M Thijs, Sigrid C. J. De Keersmaecker, Abeer Fadda — 2007
• Adrenaline modulates the global transcriptional profile of Salmonella revealing a role in the antimicrobial peptide and oxidative stress resistance responsesMH Karavolos, Hannah Spencer, David M. Bulmer — 2008
• Genomic Profiling of Iron-Responsive Genes in Salmonella enterica Serovar Typhimurium by High-Throughput Screening of a Random Promoter LibraryJaime Bjarnason, Carolyn M. Southward, Michael G. Surette — 2003
• A flagellar gene fliZ regulates the expression of invasion genes and virulence phenotype in Salmonella enterica serovar Typhimurium.Sunao Iyoda, Tomokazu Kamidoi, Kenji Hirose — 2001
• Treatment of Chlamydia trachomatis with a small molecule inhibitor of the Yersinia type III secretion system disrupts progression of the chlamydial developmental cycleKaterina Wolf, Helen J. Betts, Blandine Chellas-Géry — 2006
• Bacterial virulence as a target for antimicrobial chemotherapy.Lefa Alksne, Steven J. Projan — 2000
• Protein delivery into eukaryotic cells by type III secretion machinesJorge E. Galán, Hans Wolf‐Watz — 2006
• A small-molecule inhibitor of type III secretion inhibits different stages of the infectious cycle of Chlamydia trachomatisSandra Muschiol, Leslie Bailey, Åsa Gylfe — 2006
• Cytotoxicity of salicylaldehyde benzoylhydrazone analogs and their transition metal complexes: quantitative structure-activity relationships.Eric W. Ainscough, Andrew M. Brodie, William A. Denny — 1999
• Small molecule inhibitors of the Yersinia type III secretion system impair the development of Chlamydia after entry into host cellsSandra Muschiol, Staffan Normark, Birgitta Henriques‐Normark — 2009
• Characterization of the Effects of Salicylidene Acylhydrazide Compounds on Type III Secretion in Escherichia coli O157:H7Jai J. Tree, Dai Wang, Carol McInally — 2009
• Small-Molecule Type III Secretion System Inhibitors Block Assembly of the Shigella Type III SecretonAndreas K. J. Veenendaal, Charlotta Sundin, Ariel Blocker — 2008
• Global transcriptional responses of Pseudomonas syringae DC3000 to changes in iron bioavailability in vitroPhilip A. Bronstein, Melanie J. Filiatrault, Christopher R. Myers — 2008

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• Proton and gallium(III) binding properties of a biologically active salicylidene acylhydrazide.Zulmira C. Santos — 2014
• Small Molecules as Tools in Biological Chemistry : Effects of Synthetic and Natural Products on the Type III Secretion SystemC. Zetterström — 2013
• Identification and characterization of type III secretion inhibitors in Erwinia amylovora, the causal agent of fire blight of apple and pearFan Yang — 2012
• Chemical genetics and immunomodulation in Salmonella enterica serovar typhimurium infectionSperan a Puiac, B nesaru, Viorel Banesaru — 2015
• The challenge of relating gene expression to the virulence of Salmonella enterica serovar Typhimurium.Magali Hébrard, Carsten Kröger, Sathesh K. Sivasankaran — 2011
• Mutations in hemG Mediate Resistance to Salicylidene Acylhydrazides, Demonstrating a Novel Link between Protoporphyrinogen Oxidase (HemG) and Chlamydia trachomatis InfectivityPatrik Engström, Bidong D. Nguyen, Johan Normark — 2013
• Development of Antivirulence Compounds: A Biochemical ReviewRiccardo Zambelloni, Rodolfo Márquez, Andrew J. Roe — 2015
• Small-molecular virulence inhibitors show divergent and immunomodulatory effects in infection models of Salmonella enterica serovar Typhimurium.Speranta Puiac, Xiaohui Sem, Aurel Negrea — 2011
• Targeting the type III secretion system to treat bacterial infectionsNatalie C. Marshall, B. Brett Finlay — 2014
• Salmonella Adhesion, Invasion and Cellular Immune Responses Are Differentially Affected by Iron Concentrations in a Combined In Vitro Gut Fermentation-Cell ModelAlexandra Dostal, Mélanie Gagnon, Christophe Chassard — 2014
• Isolation of Salmonella Mutants Resistant to the Inhibitory Effect of Salicylidene acylhydrazides on Flagella-Mediated MotilityIsabel Martínez‐Argudo, Andreas K. J. Veenendaal, Xia Liu — 2013
• The Bacterial Type III Secretion System as a Target for Developing New AntibioticsAndrew C. McShan, Roberto N. De Guzman — 2015
• Small-molecule inhibitors suppress the expression of both type III secretion and amylovoran biosynthesis genes in Erwinia amylovora.Fan Yang, Schuyler S. Korban, P.L. Pusey — 2014
• Effects of iron supplementation on dominant bacterial groups in the gut, faecal SCFA and gut inflammation: a randomised, placebo-controlled intervention trial in South African childrenAlexandra Dostal, Jeannine Baumgartner, Nathalie Riesen — 2014
• From screen to target: insights and approaches for the development of anti-virulence compoundsKatherine S. H. Beckham, Andrew J. Roe — 2014
• Chemical Inhibitors of the Type Three Secretion System: Disarming Bacterial PathogensMiles C. Duncan, Roger G. Linington, Victoria Auerbuch — 2012
• Influence of chelation strength and bacterial uptake of gallium salicylidene acylhydrazide on biofilm formation and virulence of Pseudomonas aeruginosa.Shoghik Hakobyan, Olena Rzhepishevska, Erik Björn — 2016
• Approaches targeting the type III secretion system to treat or prevent bacterial infectionsNuno Charro, Luı́s Jaime Mota — 2015
• Small molecules aimed at type III secretion systems to inhibit bacterial virulenceLun K. Tsou, Paul D. Dossa, Howard C. Hang — 2012
• Cytosporone B, an Inhibitor of the Type III Secretion System of Salmonella enterica Serovar TyphimuriumJianfang Li, Chao Lv, Weiyang Sun — 2013

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