Anthelmintic activity of artesunate against Fasciola hepatica in naturally infected sheep.
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Summary
Three sheep died 24-72 h post-treatment with a double dose of 40 mg/kg intramuscular artesunate, showing lethargy, sialorrhoea, reduced rumination and tremors, warrant further investigations with an emphasis on toxicity studies.
- Type
- article
- Published
- 2010-02-01
- Cited by
- 54
- References
- 26
- OpenAlex
- https://openalex.org/W2013733279
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:8869210
Keywords
Artesunate, Fasciola hepatica, Triclabendazole, Anthelmintic, Veterinary medicine
References
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- Screening for Indian isolates of egg-parasitic fungi for use in biological control of fascioliasis and amphistomiasis in ruminant livestock
- Differential effects of orally versus parenterally administered qinghaosu derivative artemether in dogs
- Triclabendazole for the treatment of fascioliasis and paragonimiasis
- Fasciola hepatica: tegumental alterations in adult flukes following in vitro and in vivo administration of artesunate and artemether.
- Emerging Foodborne Trematodiasis
- Food-borne trematodiasis: current chemotherapy and advances with artemisinins and synthetic trioxolanes.
- The influence of flotation solution, sample dilution and the choice of McMaster slide area (volume) on the reliability of the McMaster technique in estimating the faecal egg counts of gastrointestinal strongyles and Dicrocoelium dendriticum in sheep.
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- Qinghaosu (Artemisinin): The Price of Success
- Identification of an antimalarial synthetic trioxolane drug development candidate
- The Pharmacokinetics and Bioavailability of Dihydroartemisinin, Arteether, Artemether, Artesunic Acid and Artelinic Acid in Rats
- Advances in the discovery and development of trematocidal drugs
- Activity of artemether and OZ78 against triclabendazole-resistant Fasciola hepatica.
- Efficacy and safety of artemether against a natural Fasciola hepatica infection in sheep
- Fasciola hepatica: Surface tegumental responses to in vitro and in vivo treatment with the experimental fasciolicide OZ78.
- Pharmacokinetic parameters of artesunate and dihydroartemisinin in rats infected with Fasciola hepatica.
Cited by
- Anthelminthic effects of artemisinin and its derivatives
- A comparative study on the impact of two artemisinin derivatives, artemether and artesunate, on the female reproductive system of Fasciola hepatica.
- Peroxidation of β-diketones and β-keto esters with tert-butyl hydroperoxide in the presence of Cu(ClO4)2/SiO2
- The drugs we have and the drugs we need against major helminth infections.
- Organocatalytic peroxidation of malonates, β-ketoesters, and cyanoacetic esters using n-Bu4NI/t-BuOOH-mediated intermolecular oxidative C(sp3)–O coupling
- Six Peroxide Groups in One Molecule – Synthesis of Nine-Membered Bicyclic Silyl Peroxides
- Evaluation of the pharmacokinetic profile of artesunate, artemether and their metabolites in sheep naturally infected with Fasciola hepatica.
- General methods for the preparation of 1,2,4,5-tetraoxanes – key structures for the development of peroxidic antimalarial agents
- Update on the diagnosis and treatment of food-borne trematode infections
- Efficacy, safety and pharmacokinetics of 1,2,4-trioxolane OZ78 against an experimental infection with Fasciola hepatica in sheep.
- Reducing the future threat from (liver) fluke: realistic prospect or quixotic fantasy?
- Manganese triacetate as an efficient catalyst for bisperoxidation of styrenes.
- Phosphomolybdic and phosphotungstic acids as efficient catalysts for the synthesis of bridged 1,2,4,5-tetraoxanes from β-diketones and hydrogen peroxide.
- In Vivo and In Vitro Sensitivity of Fasciola hepatica to Triclabendazole Combined with Artesunate, Artemether, or OZ78
- FLOTAC: new multivalent techniques for qualitative and quantitative copromicroscopic diagnosis of parasites in animals and humans
- Development and validation of a liquid chromatography and ion spray tandem mass spectrometry method for the quantification of artesunate, artemether and their major metabolites dihydroartemisinin and dihydroartemisinin-glucuronide in sheep plasma.
- Selective synthesis of cyclic peroxides from triketones and H2O2.
- Nature Chooses Rings: Synthesis of Silicon-Containing Macrocyclic Peroxides
- Anthelmintic activity of Artemisia annua L. extracts in vitro and the effect of an aqueous extract and artemisinin in sheep naturally infected with gastrointestinal nematodes
- Ultrastructural changes in the tegument and gut of adult Fasciola hepatica following in vivo treatment with artesunate.
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