The coffee diterpene kahweol induces heme oxygenase‐1 via the PI3K and p38/Nrf2 pathway to protect human dopaminergic neurons from 6‐hydroxydopamine‐derived oxidative stress
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Summary
Results suggest that regulation of the anti‐oxidant enzyme HO‐1 via the PI3K and p38/Nrf2 signaling pathways controls the intracellular levels of ROS.
- Type
- article
- Published
- 2008-07-23
- Cited by
- 146
- References
- 19
- Access
- Open access
- OpenAlex
- https://openalex.org/W2013680091
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11309320
Keywords
Neuroprotection, Hydroxydopamine, Heme oxygenase, Oxidative stress, Neurotoxin
References
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- Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles.
- Induction of cytoprotective genes through Nrf2/antioxidant response element pathway: a new therapeutic approach for the treatment of inflammatory diseases.
- Induction of xenobiotic enzymes by the map kinase pathway and the antioxidant or electrophile response element (ARE/EpRE),†,‡
- In vitro antioxidant activity of coffee compounds and their metabolites.
- Protective effects of kahweol and cafestol against hydrogen peroxide-induced oxidative stress and DNA damage.
- Transcriptional regulation of the heme oxygenase-1 gene via the stress response element pathway.
- Heme oxygenase-1 attenuates vascular remodeling following balloon injury in rat carotid arteries.
- PI3K is a key molecule in the Nrf2‐mediated regulation of antioxidative proteins by hemin in human neuroblastoma cells
- Regulation of Heme Oxygenase-1 Expression through the Phosphatidylinositol 3-Kinase/Akt Pathway and the Nrf2 Transcription Factor in Response to the Antioxidant Phytochemical Carnosol*
- Chemopreventive effects of coffee bean and rice constituents on colorectal carcinogenesis.
- Heme oxygenase-1: a novel therapeutic target in oxidative tissue injuries.
- Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications
- Bilirubin: An Endogenous Product of Heme Degradation with Both Cytotoxic and Cytoprotective Properties
- Neuronal cell death.
Cited by
- Comparison between proliferative and neuron-like SH-SY5Y cells as an in vitro model for Parkinson disease studies.
- The antifibrotic and fibrolytic properties of date fruit extract via modulation of genotoxicity, tissue-inhibitor of metalloproteinases and nuclear factor- kappa B pathway in a rat model of hepatotoxicity
- Involvement of endogenous opioid peptides in the peripheral antinociceptive effect induced by the coffee specific diterpene kahweol
- Protective effects of Chunghyuldan against ROS-mediated neuronal cell death in models of Parkinson's disease.
- Exploring in vitro neurobiological effects and high-pressure liquid chromatography-assisted quantitation of chlorogenic acid in 18 Turkish coffee brands
- Sanguisorbae Radix Protects Against 6‐Hydroxydopamine‐induced Neurotoxicity by Regulating NADPH Oxidase and NF‐E2‐related Factor‐2/Heme Oxygenase‐1 Expressions
- MicroRNA-7 activates Nrf2 pathway by targeting Keap1 expression
- Isoalantolactone from Inula helenium Caused Nrf2-Mediated Induction of Detoxifying Enzymes
- Berberine protects 6-hydroxydopamine-induced human dopaminergic neuronal cell death through the induction of heme oxygenase-1
- Induction of Heme Oxygenase-1 by Na+-H+ Exchanger 1 Protein Plays a Crucial Role in Imatinib-resistant Chronic Myeloid Leukemia Cells*
- Role of Heme Oxygenase in Inflammation, Insulin-Signalling, Diabetes and Obesity
- Involvement of Nrf2 signaling pathway in the neuroprotective activity of natural kaurane diterpenes.
- Protective effect of creatine against 6-hydroxydopamine-induced cell death in human neuroblastoma SH-SY5Y cells: Involvement of intracellular signaling pathways.
- Downregulation of Nrf2/HO-1 pathway and activation of JNK/c-Jun pathway are involved in homocysteic acid-induced cytotoxicity in HT-22 cells.
- The coffee diterpene kahweol prevents osteoclastogenesis via impairment of NFATc1 expression and blocking of Erk phosphorylation.
- Cytoprotective effects of 12-oxo phytodienoic acid, a plant-derived oxylipin jasmonate, on oxidative stress-induced toxicity in human neuroblastoma SH-SY5Y cells.
- Coffee and cancer risk, epidemiological evidence, and molecular mechanisms.
- Non-esterified fatty acids activate the ROS–p38–p53/Nrf2 signaling pathway to induce bovine hepatocyte apoptosis in vitro
- RETRACTED: S-allyl cysteine protects against 6-hydroxydopamine-induced neurotoxicity in the rat striatum: involvement of Nrf2 transcription factor activation and modulation of signaling kinase cascades.
- Signaling pathways activated by the phytochemical nordihydroguaiaretic acid contribute to a Keap1-independent regulation of Nrf2 stability: Role of glycogen synthase kinase-3.
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