Comparison between proliferative and neuron-like SH-SY5Y cells as an in vitro model for Parkinson disease studies.
Explore this paper's citation graph
Summary
The data suggest that SH-SY5Y cells differentiated by 7 days with the protocol described here represent a more suitable experimental model for studying the molecular and cellular mechanisms underlying the pathophysiology of PD.
- Type
- dissertation
- Published
- 2010-06-14
- Cited by
- 394
- References
- 55
- OpenAlex
- https://openalex.org/W20380819
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:22308005
Keywords
Humanities, Art
References
- A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.
- Molecular Pathways of Neurodegeneration in Parkinson's Disease
- The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis.
- DJ‐1‐binding compounds prevent oxidative stress‐induced cell death and movement defect in Parkinson’s disease model rats
- Identification of major cell classes in the developing mammalian nervous system
- Mechanisms of DJ‐1 neuroprotection in a cellular model of Parkinson’s disease
- Protective effects of astaxanthin on 6‐hydroxydopamine‐induced apoptosis in human neuroblastoma SH‐SY5Y cells
- Neuroblastoma Cells Expressing the Noradrenaline Transporter Are Destroyed More Selectively by 6‐Fluorodopamine than by 6‐Hydroxydopamine
- Cholesterol supports the retinoic acid‐induced synaptic vesicle formation in differentiating human SH‐SY5Y neuroblastoma cells
- Nestin Modulates Glucocorticoid Receptor Function by Cytoplasmic Anchoring
- Retinoic acid-induced differentiation of cultured human neuroblastoma cells: a comparison with phorbolester-induced differentiation.
- Extracellular guanosine and GTP promote expression of differentiation markers and induce S‐phase cell‐cycle arrest in human SH‐SY5Y neuroblastoma cells
- Activation of the Phosphatidylinositol 3-Kinase/Akt Signaling Pathway by Retinoic Acid Is Required for Neural Differentiation of SH-SY5Y Human Neuroblastoma Cells*
- Protective effects of green tea polyphenols and their major component, (–)-epigallocatechin-3-gallate (EGCG), on 6-hydroxydopamine-induced apoptosis in PC12 cells
- The 6-hydroxydopamine model: news from the past.
- Differential effects of 24‐hydroxycholesterol and 27‐hydroxycholesterol on tyrosine hydroxylase and α‐synuclein in human neuroblastoma SH‐SY5Y cells
- Oxidative insults induce DJ-1 upregulation and redistribution: implications for neuroprotection.
- DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2
- The coffee diterpene kahweol induces heme oxygenase‐1 via the PI3K and p38/Nrf2 pathway to protect human dopaminergic neurons from 6‐hydroxydopamine‐derived oxidative stress
- Baicalein exerts neuroprotective effects in 6-hydroxydopamine-induced experimental parkinsonism in vivo and in vitro.
Cited by
- Neuroprotective effects of metabotropic glutamate receptor group II and III activators against MPP(+)-induced cell death in human neuroblastoma SH-SY5Y cells: the impact of cell differentiation state.
- The unfolded protein response in the therapeutic effect of hydroxy-DHA against Alzheimer’s disease
- Graphene Oxide–Silver Nanoparticles Nanocomposite Stimulates Differentiation in Human Neuroblastoma Cancer Cells (SH-SY5Y)
- Neuroepithelial control of mucosal inflammation in acute cystitis
- Estudi en mostres humanes i en cultius neuronals d’indicadors del sistema glutamatèrgic i dopaminèrgic en relació a l’exposició prolongada a contaminants orgànics tòxics persistents
- MICROTUBULE DYNAMICS IN OXIDATIVELY-STRESSED NEURONAL CELLS
- Neuropatia diabética : estudo dos mecanismos moleculares envolvidos com a neurotoxicidade do metilglioxal e do glicolaldeído em células diferenciadas de neuroblastoma humano SH-SY5Y
- Padronização de protocolo de imunofluorescência em microscopia confocal para avaliação de alterações bioquímicas e citomorfológicas induzidas pela neurotoxina 6-hidroxidopamina à linhagem celular SH-SY5H
- Ammonia-induced oxidative damage in neurons is prevented by resveratrol and lipoic acid with participation of heme oxygenase 1.
- Regulation of mitochondrial biogenesis in human embryonic stem cells
- Characterizations of a synthetic pituitary adenylate cyclase-activating polypeptide analog displaying potent neuroprotective activity and reduced in vivo cardiovascular side effects in a Parkinson's disease model.
- Ecstasy¿s Neurotoxicity: In Vitro Findings from Mitochondria to the Cell
- Interferência de RNA para silenciamento gênico da enzima NO sintase neuronal (nNOS) no modelo in vitro de neurodegeneração por interferon gama
- Epigenetic Regulation of Cytosolic Phospholipase A2 in SH-SY5Y Human Neuroblastoma Cells
- Polyelectrolyte-coated nanocapsules containing undecylenic acid: Synthesis, biocompatibility and neuroprotective properties.
- Exploring the secretome of mesenchymal like stem cells for central nervous system regenerative medicine: a focus on Parkinson's disease
- The Evolutionarily Conserved LIM Homeodomain Protein LIM-4/LHX6 Specifies the Terminal Identity of a Cholinergic and Peptidergic C. elegans Sensory/Inter/Motor Neuron-Type
- Covalent functionalization enables good dispersion and anisotropic orientation of multi-walled carbon nanotubes in a poly(l-lactic acid) electrospun nanofibrous matrix boosting neuronal differentiation
- Parkinson's disease cybrids, differentiated or undifferentiated, maintain morphological and biochemical phenotypes different from those of control cybrids
- BDNF translational control as a therapeutic target in Rett syndorme
Related papers
No related papers recorded.