Lipid Profiling following Intake of the Omega 3 Fatty Acid DHA Identifies the Peroxidized Metabolites F4-Neuroprostanes as the Best Predictors of Atherosclerosis Prevention
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Summary
Targeted lipidomic analyses revealed that both the profiles of EPA and DHA and their corresponding oxygenated metabolites were substantially modulated in plasma and liver, and oxygenated n-3 PUFAs, and F4-neuroprostanes in particular are potential biomarkers of DHA-associated atherosclerosis prevention.
- Type
- article
- Published
- 2014-02-18
- Cited by
- 79
- References
- 55
- Access
- Open access
- OpenAlex
- https://openalex.org/W2013671349
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:14685536
Keywords
Docosahexaenoic acid, Eicosapentaenoic acid, Polyunsaturated fatty acid, Chemistry, Oxidative stress
References
- Stereocontrolled access to isoprostanes via a bicyclo[3.3.0]octene framework.
- An Analysis of Transformations
- The fatty acid oxidation product 15-A3t-Isoprostane is a potent inhibitor of NFκB transcription and macrophage transformation
- Retroconversion and metabolism of [13C]22:6n-3 in humans and rats after intake of a single dose of [13C]22:6n-3-triacylglycerols.
- Fish oil increases cholesterol storage in white adipose tissue with concomitant decreases in inflammation, hepatic steatosis, and atherosclerosis in mice.
- Fish intake is associated with a reduced progression of coronary artery atherosclerosis in postmenopausal women with coronary artery disease.
- Increasing intake of long-chain n-3 PUFA enhances lipoperoxidation and modulates hepatic gene expression in a dose-dependent manner
- Reduction in Dietary Omega-6 Polyunsaturated Fatty Acids:Eicosapentaenoic Acid plus Docosahexaenoic Acid Ratio Minimizes Atherosclerotic Lesion Formation and Inflammatory Response in the LDL Receptor Null Mouse
- The role of marine omega-3 (n-3) fatty acids in inflammatory processes, atherosclerosis and plaque stability.
- Electrophilic Cyclopentenone Neuroprostanes Are Anti-inflammatory Mediators Formed from the Peroxidation of the ω-3 Polyunsaturated Fatty Acid Docosahexaenoic Acid*
- Orally administered eicosapentaenoic acid reduces and stabilizes atherosclerotic lesions in ApoE-deficient mice.
- Inhibition of phagocyte-endothelium interactions by oxidized fatty acids: a natural anti-inflammatory mechanism?
- n-3 fatty acids: Antiatherosclerotic effects
- Isoprostane Generation and Function
- Formation of Highly Reactive Cyclopentenone Isoprostane Compounds (A3/J3-Isoprostanes) in Vivo from Eicosapentaenoic Acid*
- Dose-Response Effect of Dietary Docosahexaenoic Acid on Fatty Acid Profiles of Serum and Tissue Lipids in Rats.
- Workshop statement on the essentiality of and recommended dietary intakes for Omega-6 and Omega-3 fatty acids.
- The kinetics of the autoxidation of polyunsaturated fatty acids
- Detection of omega-3 oxylipins in human plasma and response to treatment with omega-3 acid ethyl esters[S]
- Cereal fiber and whole-grain intake are associated with reduced progression of coronary-artery atherosclerosis in postmenopausal women with coronary artery disease.
Cited by
- The omega-3 fatty acid docosahexaenoic acid favorably modulates the inflammatory pathways and macrophage polarization within aorta of LDLR−/− mice
- Docosahexaenoic acid regulates gene expression in HUVEC cells treated with polycyclic aromatic hydrocarbons.
- Socio-economic dynamics and innovative technologies affecting health-related lipid content in diets: Implications on global food and nutrition security
- Non-enzymatic cyclic oxygenated metabolites of omega-3 polyunsaturated fatty acid: Bioactive drugs?
- Dietary DHA reduces downstream endocannabinoid and inflammatory gene expression and epididymal fat mass while improving aspects of glucose use in muscle in C57BL/6J mice
- Antioxidant supplementation and obesity have independent effects on hepatic oxylipin profiles in insulin-resistant, obesity-prone rats.
- Nutrigenomic effects of omega‐3 fatty acids
- Endogenous Generation and Signaling Actions of Omega-3 Fatty Acid Electrophilic Derivatives
- DHA at nutritional doses restores insulin sensitivity in skeletal muscle by preventing lipotoxicity and inflammation.
- Current molecular diagnostics of cardiovascular diseases -a step closer to personalized medicine.
- 0006 : Non-enzymatic lipid mediators, neuroprostanes exerts the anti-arrhythmic properties of docosahexaenoic acid
- Targeted metabolomics of the arachidonic acid cascade: current state and challenges of LC–MS analysis of oxylipins
- Unresolved issues in the analysis of F2-isoprostanes, F4-neuroprostanes, isofurans, neurofurans, and F2-dihomo-isoprostanes in body fluids and tissue using gas chromatography/negative-ion chemical-ionization mass spectrometry
- Polymorphism of rs7688672 and rs10033237 in cGKII/PRKG2 and gout susceptibility of Han population in northern China.
- Non-enzymatic cyclic oxygenated metabolites of adrenic, docosahexaenoic, eicosapentaenoic and α-linolenic acids; bioactivities and potential use as biomarkers.
- Omega-3 polyunsaturated fatty acids and oxygenated metabolism in atherothrombosis.
- Effect of Omega-3 Fatty Acid Ethyl Esters on the Oxylipin Composition of Lipoproteins in Hypertriglyceridemic, Statin-Treated Subjects
- Altered erythrocyte membrane fatty acid profile in typical Rett syndrome: effects of omega-3 polyunsaturated fatty acid supplementation.
- Comparison of the effects of long-chain omega-3 fatty acid supplementation on plasma levels of free and esterified oxylipins
- Special Issue on “Analytical Methods for Oxidized Biomolecules and Antioxidants” The use of isoprostanoids as biomarkers of oxidative damage, and their role in human dietary intervention studies
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