Genetic linkage studies.
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Summary
This work provides an introduction to methods commonly used to map loci that predispose to disease and discusses the role of simulation in assessment of statistical significance and estimation of power.
- Type
- review
- Published
- 2005-09-17
- Cited by
- 303
- References
- 50
- OpenAlex
- https://openalex.org/W2013376909
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:34882295
Keywords
Linkage (software), Genetic linkage, Genetics, Parametric statistics, Computational biology
References
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- Haseman and Elston revisited
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- On the lod score method in linkage analysis
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- Evaluating the results of genomewide linkage scans of complex traits by locus counting.
- A systematic genomewide linkage study in 353 sib pairs with schizophrenia.
- Ehlers-Danlos syndrome with severe early-onset periodontal disease (EDS-VIII) is a distinct, heterogeneous disorder with one predisposition gene at chromosome 12p13.
- The Genetics of Adult-Onset Neuropsychiatric Disease: Complexities and Conundra?
- Replication of linkage studies of complex traits: an examination of variation in location estimates.
- Whole-genome scan, in a complex disease, using 11,245 single-nucleotide polymorphisms: comparison with microsatellites.
- Likelihood‐ratio affected sib‐pair tests applied to multiply affected sibships: Issues of power and type I error rate
- A class of tests for linkage using affected pedigree members.
Cited by
- Pharmacogenetics of anti-TNF treatment in patients with rheumatoid arthritis.
- Genomewide Linkage in a Large Dutch Family With Intracranial Aneurysms: Replication of 2 Loci for Intracranial Aneurysms to Chromosome 1p36.11-p36.13 and Xp22.2-p22.32
- Molecular Genetic Studies of ALSG, Kostmann Syndrome and a Novel Chromosome 10 Inversion
- Three -dimensional morphometric analysis of the craniofacial complex in the unaffected relatives of individuals with nonsyndromic orofacial clefts
- Prostate cancer aetiology : epidemiological studies of the IGF- and one-carbon metabolism pathways
- Diagnostic Evaluation of Schizophrenia for Genetic Studies
- Genetic studies of diabetes in northern Sweden
- Genetic and epidemiological study of Migraine.
- Hereditary diffuse leukoencephalopathy with spheroids: Insights into an adult onset neurodegenerative disease
- Genetic factors involved in stroke susceptibility and in outcome at three months
- The molecular genetics of insulin secretion and signalling
- A GENÉTICA NA IMUNOPATOGÉNESE DA NEFROPATIA IgA
- Perspectiva genética nas perturbações da ansiadade
- Epistasis, complexity, and multifactor dimensionality reduction.
- Genetics, Health Care and Public Policy: Index
- Is the endothelial nitric oxide synthase (eNOS) gene a susceptibility gene for coronary artery disease, hypertension and type 2 diabetes among North Indian populations?
- Genetic Basis of Inherited Eye Diseases
- Étude des déterminants génétiques et environnementaux des complications du diabète de type 2
- Analysis of genetic variation within urotensin-II system in regulation of blood pressure and renal function
- Identification of loci for migraine with aura
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