Re-evaluating the Roles of Proposed Modulators of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling*
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Summary
It is suggested that uncharged tRNALeu does not switch off mTORC1 signaling and suggest that m TORC1 is controlled by a distinct pathway that senses the availability of amino acids.
- Type
- article
- Published
- 2008-11-07
- Cited by
- 152
- References
- 55
- Access
- Open access
- OpenAlex
- https://openalex.org/W2012865029
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25807725
Keywords
RHEB, mTORC1, Amino acid, Biochemistry, Biology
References
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- Expanding mTOR signaling
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- mTOR and cancer therapy
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- Characterization of cell lines showing growth control isolated from both the wild type and a leucyl‐tRNA synthetase mutant of chinese hamster ovary cells
- Regulation of the small GTPase Rheb by amino acids
- Cell size regulation by the human TSC tumor suppressor proteins depends on PI3K and FKBP38
- Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPase
- A mammalian cell mutant with a temperature-sensitive leucyl-transfer RNA synthetase.
Cited by
- Regulation of TOR by small GTPases
- Long distance movement of an Arabidopsis Translationally Controlled Tumor Protein (AtTCTP2) mRNA and protein in tobacco
- CGEF-1 regulates mTORC1 signaling during adult longevity and stress response in C. elegans
- PI3K- and mTOR-dependent mechanisms of lapatinib resistance and resulting therapeutic opportunities
- Ribosomal protein S6 kinase from TOP mRNAs to cell size.
- Fission Yeast Model Study for Dissection of TSC Pathway
- Rheb G-Proteins and the Activation of mTORC1
- Hormonal and Nutrient Signalling to Protein Kinase B and Mammalian Target of Rapamycin in Pancreatic Beta-Cells
- The Regulation of Mammalian Target of Rapamycin
- TOR signalling in plants.
- Rheb signaling and tumorigenesis: mTORC1 and new horizons
- Characterising the signalling mechanism of the mTOR-dependent phosphatase
- mTOR inhibition as a therapeutic strategy in tuberous sclerosis or sporadic lymphangioleiomyomatosis
- Identifying and characterising downstream substrates of mTORC1
- Regulation of mTORC1 by PI3K Signaling
- Regulation of the Target of Rapamycin and Other Phosphatidylinositol 3-Kinase-Related Kinases by Membrane Targeting
- Molecular Basis of the Acceleration of the GDP-GTP Exchange of Human Ras Homolog Enriched in Brain by Human Translationally Controlled Tumor Protein*
- TPT1/ TCTP-regulated pathways in phenotypic reprogramming.
- Amino Acids Activate Mammalian Target of Rapamycin Complex 2 (mTORC2) via PI3K/Akt Signaling*
- Evaluation of mTOR function by a gain-of-function approach
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