How introns influence and enhance eukaryotic gene expression.
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Summary
Recent progress is summarized in understanding of how introns and the act of their removal by the spliceosome can influence and enhance almost every step of mRNA metabolism.
- Type
- review
- Published
- 2003-04-01
- Cited by
- 739
- References
- 67
- OpenAlex
- https://openalex.org/W2012709143
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4842743
Keywords
Intron, Spliceosome, Biology, Gene, RNA splicing
References
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- Regulation of alternative splicing by RNA editing
- Regulation of human immunodeficiency virus env expression by the rev gene product
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- Simian virus 40 late transcripts lacking excisable intervening sequences are defective in both stability in the nucleus and transport to the cytoplasm
- U1 snRNP inhibits pre-mRNA polyadenylation through a direct interaction between U1 70K and poly(A) polymerase.
- The mago nashi gene is required for the polarisation of the oocyte and the formation of perpendicular axes in Drosophila.
- A role for transcription and FRGY2 in masking maternal mRNA within Xenopus oocytes.
- U1 snRNA associates with TFIIH and regulates transcriptional initiation
- Introns increase gene expression in cultured maize cells.
- Commitment of apolipoprotein B RNA to the splicing pathway regulates cytidine-to-uridine editing-site utilization.
- Integrating mRNA processing with transcription.
- Splicing factors SRp20 and 9G8 promote the nucleocytoplasmic export of mRNA.
- Quality control of mRNA function.
- Magoh, a human homolog of Drosophila mago nashi protein, is a component of the splicing‐dependent exon–exon junction complex
- Nuclear coupling: RNA processing reaches back to transcription
- The role of the cap structure in RNA processing and nuclear export.
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- On the right track
- Polymorphisms in the delta-like 2 homolog gene and their association with growth and meat-quality traits in Qinchuan cattle.
- The exon junction complex as a node of post-transcriptional networks
- The exon junction complex: a lifelong guardian of mRNA fate
- The Effect of ICOS Polymorphism Interactions with HBV Mutations on HBV Subtype Infection Outcomes.
- Functions of the Heterologous Intron-Derived Fragments Intra and Extra Factor IX-cDNA Coding Region on the Human Factor IX Expression in HepG2 and Hek-293T Cells
- Recombinant protein production by transient gene transfer into Mammalian cells.
- The 5'-UTR intron of the midgut-specific BmAPN4 gene affects the level and location of expression in transgenic silkworms.
- Estudio de la evolución de un fitopatógeno: Genómica comparada del hongo patógeno de maíz Colletotrichum graminicola
- Genetic and Functional Analysis of Host Genes Involved in Pathogenic and Symbiotic Legume-Microbe Interactions
- Novel Introner-Like Elements in fungi Are Involved in Parallel Gains of Spliceosomal Introns
- Characterization of 5 UTR splicing and the CGI in HIV-2 RNA
- Late Embryogenesis Abundant (LEA) Gene Family in Maize: Identification, Evolution, and Expression Profiles
- The Phenome-Wide Distribution of Genetic Variance
- DIRECIONAMENTO DE PEPTÍDEOS TOLEROGÊNICOS DA PROTEÍNA DE CHOQUE TÉRMICO 60 PARA CÉLULAS DENDRÍTICAS UTILIZANDO ANTICORPOS ANTI-DEC-205
- Mutationsanalyse in ABCA4-assoziierten Netzhautdystrophien mittels der Didesoxymethode nach Sanger
- Molecular Evolution of Gene Expression and Protein Function in the Genera Flaveria (Asteraceae) and Alternanthera (Amaranthaceae): Phosphoenolpyruvate Carboxylase and Glycine Decarboxylase
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