Comparison of intron-dependent and intron-independent gene expression
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Summary
Sequences from the transcribed region of the herpes simplex virus thymidine kinase gene, a gene that lacks an intervening sequence, permitted substantial intron-independent expression (greater than 100-fold increase) in the plasmid vector system.
- Type
- article
- Published
- 1988-10-01
- Cited by
- 376
- References
- 62
- Access
- Open access
- OpenAlex
- https://openalex.org/W1783181079
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25252807
Keywords
Biology, Intron, Polyadenylation, RNA splicing, Molecular biology
References
- Mutational alterations within the simian virus 40 leader segment generate altered 16S and 19S mRNA's
- Complex regulation of simian virus 40 early-region transcription from different overlapping promoters
- Simian virus 40 early- and late-region promoter functions are enhanced by the 72-base-pair repeat inserted at distant locations and inverted orientations
- Plasmid-directed synthesis of hepatitis B surface antigen in monkey cells
- Expression of the mouse dihydrofolate reductase complementary deoxyribonucleic acid in simian virus 40 vectors
- Two mRNAs can be produced from a single immunoglobulin mu gene by alternative RNA processing pathways.
- A catalogue of splice junction sequences.
- Structure and genomic organization of the mouse dihydrofolate reductase gene.
- Attenuation in the control of expression of bacterial operons
- Somatic generation of antibody diversity.
- Stepwise assembly of a pre-mRNA splicing complex requires U-snRNPs and specific intron sequences.
- Transformation of rat cells by an altered polyoma virus genome expressing only the middle-T protein
- Unusual splice sites revealed by mutagenic inactivation of an authentic splice site of the rabbit β-globin gene
- Selection for animal cells that express the Escherichia coli gene coding for xanthine-guanine phosphoribosyltransferase.
- A minimal intron length but no specific internal sequence is required for splicing the large rabbit beta-globin intron.
- Transcriptional enhancer elements in the mouse immunoglobulin heavy chain locus.
- Drosophila has one myosin heavy-chain gene with three developmentally regulated transcripts.
- The "spliceosome": yeast pre-messenger RNA associates with a 40S complex in a splicing-dependent reaction.
- Phenotypic expression in E. coli of a DNA sequence coding for mouse dihydrofolate reductase
- Transcription and RNA processing by the DNA tumour viruses
Cited by
- The Regulation of Gene Expression in Transformed Maize Aleurone and Endosperm Protoplasts (Analysis of Promoter Activity, Intron Enhancement, and mRNA Untranslated Regions on Expression)
- Quantitative Analysis of the Packaging Capacity of Recombinant Adeno-Associated Virus
- Construction of Portable Intron Cassettes for the Delivery and Expression of Foreign Genes
- Phosphorylation of Human Pro-Urokinase on Ser138/303 Impairs Its Receptor-dependent Ability to Promote Myelomonocytic Adherence and Motility
- The spliceosomal intron of the rolA gene of Agrobacterium rhizogenes is a prokaryotic promoter
- Transformation of Rhizoctonia solani
- Improving the post-transcriptional aspects of lentiviral vectors.
- Nucleocytoplasmic mRNA transport.
- Μελέτη της δράσης φορέων τύπου spuma που εκφράζουν anti-α σφαιρίνης shRNA (short hairpin RNA) και β-σφαιρίνη σε πειραματικά μοντέλα θαλασσαιμίας
- Requirements for Enhanced Transgene Expression by Untranslated Sequences from the Human Cytomegalovirus Immediate-Early Gene
- Comparative analysis of eukaryotic gene sequence features
- Nuclear export of herpes virus RNA.
- The first intron of rice EPSP synthase enhances expression of foreign gene
- Assembly of enhancers, promoters, and splice signals to control expression of transferred genes.
- Adding to the recombineering toolbox : interrogating internal transcriptional complexity in Caenorhabditis elegans operons via recombineered fosmid-based reporters
- Investigation of the Function and Regulation of ABC Transporters
- Gene identification by exon amplification.
- Simian virus 40 late mRNA leader sequences involved in augmenting mRNA accumulation via multiple mechanisms, including increased polyadenylation efficiency
- THE FUNCTION OF INTRON-1 OF HUMAN BETA GLOBIN GENE ON THE EXPRESSION OF BIOLOGICALLY ACTIVE HUMAN FACTOR IX IN A MAMMALIAN CELL LINE
- Studies into host macrophage transcriptional control by the African Swine Fever Virus protein A238L
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