Concise Review: Mesenchymal Stem/Multipotent Stromal Cells: The State of Transdifferentiation and Modes of Tissue Repair—Current Views
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Summary
Critically evaluate the literature describing the plasticity of MSCs and offer insight into how the molecular and functional heterogeneity of this cell population, which reflects the complexity of marrow stroma as an organ system, may confound interpretation of their transdifferentiation potential.
- Type
- review
- Published
- 2007-11-01
- Cited by
- 1,975
- References
- 143
- Access
- Open access
- OpenAlex
- https://openalex.org/W2012549032
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:1352725
Keywords
Transdifferentiation, Biology, Mesenchymal stem cell, Stem cell transplantation for articular cartilage repair, Clinical uses of mesenchymal stem cells
References
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- Epithelial-mesenchymal transitions
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- Mesenchymal Stem Cells and the Treatment of Cardiac Disease
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- Characterization and Neural Differentiation of Fetal Lung Mesenchymal Stem Cells
- Neurohormones and Catecholamines as Functional Components of the Bone Marrow Microenvironment
- Stem cell plasticity revisited: CXCR4-positive cells expressing mRNA for early muscle, liver and neural cells ‘hide out’ in the bone marrow
- Adult bone marrow stromal stem cells express germline, ectodermal, endodermal, and mesodermal genes prior to neurogenesis
- Reconstruction of Chemically Burned Rat Corneal Surface by Bone Marrow–Derived Human Mesenchymal Stem Cells
- Mesenchyme to epithelium transition during development of the mammalian kidney tubule.
- Human mesenchymal stem cells successfully improve skin‐substitute wound healing
Cited by
- Taking stem cells to the clinic: Major challenges
- Epithelial cells within the human pancreas do not coexpress mesenchymal antigens: epithelial–mesenchymal transition is an artifact of cell culture
- Reducing infection susceptibility of titanium percutaneous implants: A study of porous and smooth surfaces and mesenchymal stem cell treatments
- Hematopoietic differentiation of induced pluripotent stem cells from patients with mucopolysaccharidosis type I (Hurler syndrome).
- Construction of tissue engineered nerve grafts and their application in peripheral nerve regeneration.
- Translating Research into Clinical Scale Manufacturing of Mesenchymal Stromal Cells
- Significant clinical, neuropathological and behavioural recovery from acute spinal cord trauma by transplantation of a well-defined somatic stem cell from human umbilical cord blood.
- In vitro and in vivo osteogenesis of human mesenchymal stem cells derived from skin, bone marrow and dental follicle tissues.
- Ex vivo generation of glucose sensitive insulin secreting mesenchymal stem cells derived from human adipose tissue
- Stem cells and spinal cord injury repair.
- Cell Surface Structures Influence Lung Clearance Rate of Systemically Infused Mesenchymal Stromal Cells
- Isolation of mesenchymal stem cells from human bone and long-term cultivation under physiologic oxygen conditions.
- Snail mediates PDGF‐BB‐induced invasion of rat bone marrow mesenchymal stem cells in 3D collagen and chick chorioallantoic membrane
- Mallotus philippinensis bark extracts promote preferential migration of mesenchymal stem cells and improve wound healing in mice.
- Isolation and characterization of stem cells from the placenta and the umbilical cord.
- Tissue engineered constructs for peripheral nerve surgery
- Influence of Immune Responses in Gene/Stem Cell Therapies for Muscular Dystrophies
- Maresin-like Lipid Mediators are produced by Leukocytes and Platelets and Rescue Reparative Function of Diabetes-impaired Macrophages
- Gene delivery in tissue engineering and regenerative medicine.
- Enhanced Hepatogenic Transdifferentiation of Human Adipose Tissue Mesenchymal Stem Cells by Gene Engineering with Oct4 and Sox2
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