AHNAK and Inflammatory Markers Predict Poor Survival in Laryngeal Carcinoma
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Summary
It is found that tumoral AHNAK overexpression significantly associated with poor survival of these patients both in univariate and multivariate analysis and Synchronous high levels of all three markers were the strongest predictors of poor survival in this patient cohort.
- Type
- article
- Published
- 2013-02-07
- Cited by
- 63
- References
- 32
- Access
- Open access
- OpenAlex
- https://openalex.org/W2012449208
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:814645
Keywords
Larynx, Macrophage migration inhibitory factor, Inflammation, Carcinoma, Head and neck cancer
References
- Signaling from β‐adrenoceptor to L‐type calcium channel: identification of a novel cardiac protein kinase A target possessing similarities to AHNAK
- Cancer Statistics, 2007
- Macrophage migration inhibitory factor (MIF): a promising biomarker.
- Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesis
- The Giant Protein AHNAK Is a Specific Target for the Calcium- and Zinc-binding S100B Protein
- Macrophage migration inhibitory factor: a probable link between inflammation and cancer.
- iTRAQ-based proteomic profiling of breast cancer cell response to doxorubicin and TRAIL.
- Neutrophils and granulocytic myeloid-derived suppressor cells: immunophenotyping, cell biology and clinical relevance in human oncology
- Desmoyokin/AHNAK protein localizes to the non-desmosomal keratinocyte cell surface of human epidermis.
- Expanding Role of the Medical Oncologist in the Management of Head and Neck Cancer
- Neutrophils responsive to endogenous IFN-beta regulate tumor angiogenesis and growth in a mouse tumor model.
- Polymorphonuclear granulocytes in human head and neck cancer: Enhanced inflammatory activity, modulation by cancer cells and expansion in advanced disease
- MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment
- Tumor‐derived macrophage migration inhibitory factor modulates the biology of head and neck cancer cells via neutrophil activation
- Regulated exocytosis: a novel, widely expressed system
- A human gene (AHNAK) encoding an unusually large protein with a 1.2-microns polyionic rod structure.
- Identification of candidate cooperative genes of the Apc mutation in transformation of the colon epithelial cell by retroviral insertional mutagenesis
- Allogenic antibody-mediated identification of head and neck cancer antigens.
- Regulation of translocation of the desmoyokin/AHNAK protein to the plasma membrane in keratinocytes by protein kinase C.
- Protumor and antitumor functions of neutrophil granulocytes
Cited by
- The role of inflammation in head and neck cancer.
- RNA interference-mediated knockdown of SIRT1 and/or SIRT2 in melanoma: Identification of downstream targets by large-scale proteomics analysis
- EGF-reduced Wnt5a transcription induces epithelial-mesenchymal transition via Arf6-ERK signaling in gastric cancer cells
- AHNAK2 participates in the stress-induced nonclassical FGF1 secretion pathway
- A Gene Gravity Model for the Evolution of Cancer Genomes: A Study of 3,000 Cancer Genomes across 9 Cancer Types
- Tumor-Associated Neutrophils as a New Prognostic Factor in Cancer: A Systematic Review and Meta-Analysis
- The role of tumour FoxP3 as prognostic marker in different subtypes of head and neck cancer.
- AHNAK: the giant jack of all trades.
- STC1 expression is associated with tumor growth and metastasis in breast cancer
- Comprehensive identification of mutational cancer driver genes across 12 tumor types
- Giant scaffolding protein AHNAK1 interacts with β‐dystroglycan and controls motility and mechanical properties of schwann cells
- CD24 associates with EGFR and supports EGF/EGFR signaling via RhoA in gastric cancer cells
- Meta-analysis of transcriptome data identifies a novel 5-gene pancreatic adenocarcinoma classifier
- AHNAK is downregulated in melanoma, predicts poor outcome, and may be required for the expression of functional cadherin-1
- Brain arteriovenous malformations: implications of CEACAM1-positive inflammatory cells and sex on hemorrhage
- Current relevance of hypoxia in head and neck cancer
- AHNAK enables mammary carcinoma cells to produce extracellular vesicles that increase neighboring fibroblast cell motility
- Sex-specific clinicopathological significance of novel (Frizzled-7) and established (MGMT, IDH1) biomarkers in glioblastoma
- Neutrophils in the tumor microenvironment: trying to heal the wound that cannot heal
- LAMP1 expression is associated with malignant behaviours and predicts unfavourable prognosis in laryngeal squamous cell carcinoma.
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