Recent Advances in Defining the Immunoproteome of Mycobacterium tuberculosis
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Summary
Proteome-wide approaches to antigen discovery are reviewed and what these have revealed so far on the composition of the Mtb immunoproteome are summarized.
- Type
- review
- Published
- 2013-10-11
- Cited by
- 28
- References
- 31
- Access
- Open access
- OpenAlex
- https://openalex.org/W2012419370
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:17957151
Keywords
Proteome, Mycobacterium tuberculosis, Antigen, Immune system, Biology
References
- Specific T-Cell Epitopes for Immunoassay-Based Diagnosis of Mycobacterium tuberculosis Infection
- Comparative Analysis of Mycobacterium tuberculosis pe and ppe Genes Reveals High Sequence Variation and an Apparent Absence of Selective Constraints
- Mycobacterial PE/PPE Proteins at the Host-Pathogen Interface
- Conserved Immune Recognition Hierarchy of Mycobacterial PE/PPE Proteins during Infection in Natural Hosts
- Tubercle bacilli rely on a type VII army for pathogenicity.
- A proteome-scale identification of novel antigenic proteins in Mycobacterium tuberculosis toward diagnostic and vaccine development.
- Strong immunogenicity and cross-reactivity of Mycobacterium tuberculosis ESX-5 type VII secretion: encoded PE-PPE proteins predicts vaccine potential.
- Evasion and subversion of antigen presentation by Mycobacterium tuberculosis
- Memory T Cells in Latent Mycobacterium tuberculosis Infection Are Directed against Three Antigenic Islands and Largely Contained in a CXCR3+CCR6+ Th1 Subset
- ESAT-6 proteins: protective antigens and virulence factors?
- The PE/PPE multigene family codes for virulence factors and is a possible source of mycobacterial antigenic variation: perhaps more?
- ESX/type VII secretion systems and their role in host-pathogen interaction.
- Human T cell epitopes of Mycobacterium tuberculosis are evolutionarily hyperconserved
- Identification of Mycobacterium tuberculosis vaccine candidates using human CD4+ T-cells expression cloning
- TB subunit vaccines--putting the pieces together.
- Tuberculosis vaccines: beyond bacille Calmette–Guérin
- A Systematic Assessment of MHC Class II Peptide Binding Predictions and Evaluation of a Consensus Approach
- Comparative Genomics of esx Genes from Clinical Isolates of Mycobacterium tuberculosis Provides Evidence for Gene Conversion and Epitope Variation
- An analysis of the epitope knowledge related to Mycobacteria
- Dynamic antibody responses to the Mycobacterium tuberculosis proteome
Cited by
- Recent Trends in System-Scale Integrative Approaches for Discovering Protective Antigens Against Mycobacterial Pathogens
- Protein array identification of protein markers for serodiagnosis of Mycobacterium tuberculosis infection
- Proteome signatures—how are they obtained and what do they teach us?
- Host immune responses to mycobacterial antigens and their implications for the development of a vaccine to control tuberculosis
- Mycobacterium tuberculosis proteome microarray for global studies of protein function and immunogenicity.
- Structure of a PE–PPE–EspG complex from Mycobacterium tuberculosis reveals molecular specificity of ESX protein secretion
- Toward Understanding the Essence of Post-Translational Modifications for the Mycobacterium tuberculosis Immunoproteome
- Orchestration of pulmonary T cell immunity during Mycobacterium tuberculosis infection: immunity interruptus
- The serodominant secreted effector protein of Salmonella, SseB, is a strong CD4 antigen containing an immunodominant epitope presented by diverse HLA class II alleles
- Immunomodulatory Role of Mycobacterial PE/PPE Family of Pr oteins
- Comparative Genomics of Field Isolates of Mycobacterium bovis and M. caprae Provides Evidence for Possible Correlates with Bacterial Viability and Virulence
- Variable transcriptional adaptation between the laboratory (H37Rv) and clinical strains (S7 and S10) of Mycobacterium tuberculosis under hypoxia.
- Microbial Proteome Profiling and Systems Biology: Applications to Mycobacterium tuberculosis.
- Modular Organization of the ESX-5 Secretion System in Mycobacterium tuberculosis
- Prokaryotic Systems Biology
- Application of cutting-edge proteomics technologies for elucidating host-bacteria interactions.
- A glimpse into the modulation of post-translational modifications of human-colonizing bacteria.
- Diagnostic Performance of Tuberculosis-Specific IgG Antibody Profiles in Patients with Presumptive Tuberculosis from Two Continents
- Comparative Proteomics Analysis of Human Macrophages Infected with Virulent Mycobacterium bovis
- Tuberculosis in China: A longitudinal predictive model of the general population and recommendations for achieving WHO goals
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