Conserved Immune Recognition Hierarchy of Mycobacterial PE/PPE Proteins during Infection in Natural Hosts
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Summary
It is demonstrated that a subset of PE/PPE proteins are major targets of the cellular immune response to tuberculosis, and are recognized at multiple stages of infection and in different disease states.
- Type
- article
- Published
- 2012-08-01
- Cited by
- 60
- References
- 54
- Access
- Open access
- OpenAlex
- https://openalex.org/W2010036918
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:18745916
Keywords
Biology, Immune system, Immunodominance, Mycobacterium tuberculosis, Antigenic variation
References
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- Mobile DNA III
- Evolution and expansion of the Mycobacterium tuberculosis PE and PPE multigene families and their association with the duplication of the ESAT-6 (esx) gene cluster regions
- Characterization of a major polymorphic tandem repeat in Mycobacterium tuberculosis and its potential use in the epidemiology of Mycobacterium kansasii and Mycobacterium gordonae
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- Genome-wide requirements for Mycobacterium tuberculosis adaptation and survival in macrophages.
- Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti
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- Differential gene expression between Mycobacterium bovis and Mycobacterium tuberculosis.
- Evidence for enhanced central memory priming by live Mycobacterium bovis BCG vaccine in comparison with killed BCG formulations.
- Portrait of a Pathogen: The Mycobacterium tuberculosis Proteome In Vivo
- The PE multigene family: a 'molecular mantra' for mycobacteria.
- Isoniazid treatment of Mycobacterium bovis in cattle as a model for human tuberculosis.
- The Population Dynamics and Control of Tuberculosis
- Degradation-resistant protein domains limit host cell processing and immune detection of mycobacteria.
- Mycobacterial PE/PPE Proteins at the Host-Pathogen Interface
- Toward the structural genomics of complexes: crystal structure of a PE/PPE protein complex from Mycobacterium tuberculosis.
- Defined tuberculosis vaccine, Mtb72F/AS02A, evidence of protection in cynomolgus monkeys
- Granuloma-specific expression of Mycobacterium virulence proteins from the glycine-rich PE-PGRS family.
- Src Homology 3-interacting Domain of Rv1917c of Mycobacterium tuberculosis Induces Selective Maturation of Human Dendritic Cells by Regulating PI3K-MAPK-NF-κB Signaling and Drives Th2 Immune Responses*
Cited by
- The Microbiome at the Pulmonary Alveolar Niche: How It Affects the Human Innate Response against Mycobacterium tuberculosis
- PE11 (Rv1169c) selectively alters fatty acid components of Mycobacterium smegmatis and host cell interleukin-6 level accompanied with cell death
- Immunoregulatory functions and expression patterns of PE/PPE family members: Roles in pathogenicity and impact on anti‐tuberculosis vaccine and drug design
- Mycobacterium tuberculosis virulence: insights and impact on vaccine development.
- Nuevas estrategias para el diagnóstico de la tuberculosis y paratuberculosis bovina
- Pilon: An Integrated Tool for Comprehensive Microbial Variant Detection and Genome Assembly Improvement
- Development of an Unbiased Antigen-Mining Approach To Identify Novel Vaccine Antigens and Diagnostic Reagents for Bovine Tuberculosis
- Recent Advances in Defining the Immunoproteome of Mycobacterium tuberculosis
- Genome-wide transcription analyses in Mycobacterium tuberculosis treated with lupulone
- Toward Understanding the Essence of Post-Translational Modifications for the Mycobacterium tuberculosis Immunoproteome
- Release of mycobacterial antigens
- Evaluation of Cocktails with Recombinant Proteins of Mycobacterium bovis for a Specific Diagnosis of Bovine Tuberculosis
- Immunomodulatory Role of Mycobacterial PE/PPE Family of Pr oteins
- Antigens for CD4 and CD8 T cells in tuberculosis.
- Phylogeny to function: PE/PPE protein evolution and impact on Mycobacterium tuberculosis pathogenicity
- Gene Expression Profile and Immunological Evaluation of Unique Hypothetical Unknown Proteins of Mycobacterium leprae by Using Quantitative Real-Time PCR
- Polymorphisms in the PE35 and PPE68 antigens in Mycobacterium tuberculosis strains may affect strain virulence and reflect ongoing immune evasion.
- Mycobacterium tuberculosis PE27 activates dendritic cells and contributes to Th1-polarized memory immune responses during in vivo infection.
- Immunomodulatory Roles of PE/PPE Proteins and Their Implications in Genomic Features of Mycobacterium tuberculosis
- Mycobacterium tuberculosis Resists Stress by Regulating PE19 Expression
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