Advances in measuring cellular bioenergetics using extracellular flux.
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Summary
The extracellular flux (XF), that is the changes in oxygen and proton concentrations in the media surrounding cells, can simultaneously determine their relative state of aerobic and glycolytic metabolism, respectively, making it an attractive format for studying drug effects in vitro.
- Type
- review
- Published
- 2008-03-01
- Cited by
- 481
- References
- 39
- OpenAlex
- https://openalex.org/W2011892782
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:34109192
Keywords
Bioenergetics, Extracellular, Flux (metallurgy), Drug discovery, Cellular metabolism
References
- Nitrofurantoin and dantrolene; liver and lung.
- The use of C14O2 yields from glucose-1- and -6-C14 for the evaluation of the pathways of glucose metabolism.
- Some aspects of energy coupling by mitochondria.
- Instrumentation for process control in cell culture.
- Oxygen electrode measurements in biochemical analysis.
- Cellular energy utilization and molecular origin of standard metabolic rate in mammals.
- Early stimulation of acidification rate by novel cytotoxic pyridyl cyanoguanidines in human tumor cells: comparison with m-iodobenzylguanidine.
- Mitochondria: a historical review
- Bioenergetics of mitochondria in cultured neurons and their role in glutamate excitotoxicity
- Regulation of M2 Muscarinic Acetylcholine Receptor Expression and Signaling by Prolonged Exposure to Allosteric Modulators
- Continuous measurement of glucose utilization in heart myoblasts.
- Dantrolene sodium and hepatic injury
- Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain.
- Comparison of dantrolene sodium with erythromycin estolate using primary cultures of rat hepatocytes.
- Response of mammalian cells to controlled growth rates in steady-state continuous culture
- Detection of cell-affecting agents with a silicon biosensor.
- Mechanism of nitrofurantoin toxicity and oxidative stress in mitochondria.
- Energy Dysfunction as a Predictor of Outcome after Moderate or Severe Head Injury: Indices of Oxygen, Glucose, and Lactate Metabolism
- Verrucotoxin inhibits KATP channels in cardiac myocytes through a muscarinic M3 receptor-PKC pathway.
- The cytosensor microphysiometer: biological applications of silicon technology.
Cited by
- Phosphorescent Oxygen-Sensitive Probes
- Kinetic analysis of local oxygenation and respiratory responses of mammalian cells using intracellular oxygen-sensitive probes and time-resolved fluorometry.
- Discoveries on the storage of red blood cells and the exposure of cells in culture to xenobiotics
- Analysis of glycolytic flux as a rapid screen to identify low lactate producing CHO cell lines with desirable monoclonal antibody yield and glycan profile
- Atorvastatin protects the proliferative ability of human umbilical vein endothelial cells inhibited by angiotensin II by changing mitochondrial energy metabolism
- Methamphetamine Induces Apoptosis of Microglia via the Intrinsic Mitochondrial-Dependent Pathway
- Measuring the Effects of CTRP3 and Metformin on H4IIE Hepatocyte Metabolism Using Seahorse Extracellular Flux Analyzer
- Electrophilic Nitro-Fatty Acid Regulation of Mitochondrial Function
- Mitochondrial Oxygen Consumption by the Foreskin and its Fibroblast-rich Culture.
- Assessment of mitochondrial damage in retinal cells and tissues using quantitative polymerase chain reaction for mitochondrial DNA damage and extracellular flux assay for mitochondrial respiration activity.
- Oxygen-sensing and Mitochondrial Control of Cell Function
- Cardioprotection Resulting from Glucagon-Like Peptide-1 Administration Involves Shifting Metabolic Substrate Utilization to Increase Energy Efficiency in the Rat Heart
- Development and validation of an in vitro model to explore mechanisms of skeletal muscle toxicity
- BIOENERGETIC CHARACTERIZATION OF H9C2 CELLS USING THE EXTRACELLULAR FLUX ANALYZER.
- Blood-Cell Bioenergetics are Associated With Physical Function and Inflammation in Overweight/Obese Older Adults
- MITOCHONDRIAL AND NEUROPROTECTIVE EFFECTS OF PHENELZINE RELATED TO SCAVENGING OF NEUROTOXIC LIPID PEROXIDATION PRODUCTS
- Inhibitory Effects of Hypoxia on Metabolic Switch and Osteogenic Differentiation of Human Mesenchymal Stem Cells
- Multiscale Biodistribution Analysis of a Lipophilic, Poorly Soluble Drug
- Hypoxia Induces a Metabolic Shift and Enhances the Stemness and Expansion of Cochlear Spiral Ganglion Stem/Progenitor Cells
- Characterization of Transgenic Gfrp Knock-In Mice: Implications for Tetrahydrobiopterin in Modulation of Normal Tissue Radiation Responses
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