Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair
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Summary
It is shown that mutations in any three yeast genes involved in DNA mismatch repair lead to 100- to 700-fold increases in tract instability, whereas mutations that eliminate the proof-reading function of DNA polymerases have little effect.
- Type
- article
- Published
- 1993-09-16
- Cited by
- 1,022
- References
- 18
- OpenAlex
- https://openalex.org/W2011719683
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4280465
Keywords
DNA mismatch repair, Biology, DNA replication, Genetics, MSH2
References
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- Instability of simple sequence DNA in Saccharomyces cerevisiae
- Frameshift mutations and the genetic code. This paper is dedicated to Professor Theodosius Dobzhansky on the occasion of his 66th birthday.
- Genetic mapping of Ty elements in Saccharomyces cerevisiae
- Genetic mapping of Ty elements in Saccharomyces cerevisiae.
Cited by
- Colorectal adenoma and cancer divergence. Evidence of multilineage progression.
- Cell cycle regulation of DNA mismatch repair protein expression and activity at the H-ras oncogenic hot spot
- Mutagenesis of yeast MW104-1B strain has identified the uncharacterized PMS6 DNA mismatch repair gene locus and additional alleles of existing PMS1, PMS2 and MSH2 genes.
- Exploiting the informativity of 'meaningless' simple repetitive DNA from indirect gene diagnosis to multilocus genome scanning.
- Radiation induction of germline mutation at a hypervariable mouse minisatellite locus.
- Multiple Pathways Leading to Genomic Instabiligy and Tumorigenesis
- Complex genetic predisposition to cancer in an extended HNPCC family with an ancestral hMLH1 mutation.
- Reduced androgen receptor gene expression with first exon CAG repeat expansion.
- Molecular aspects of neuro-oncology.
- Genetics of Colonic Cancer
- Trifluoroleucine resistance and regulation of α-isopropyl malate synthase in Saccharomyces cerevisiae
- Removal of Frameshift Intermediates by Mismatch Repair Proteins in Saccharomyces cerevisiae
- Molecular diagnostics of cancer predisposition: hereditary non-polyposis colorectal carcinoma and mismatch repair defects.
- Mutagenesis assays in yeast.
- DNA damage processing defects and disease.
- DNA Methyltransferase Deficiency Modifies Cancer Susceptibility in Mice Lacking DNA Mismatch Repair
- Identification of MARCKS, FLJ11383 and TAF1B as putative novel target genes in colorectal carcinomas with microsatellite instability
- Genus-specific localization of the TaiI family of tandem-repetitive sequences in either the centromeric or subtelomeric regions in Triticeae species (Poaceae) and its evolution in wheat.
- Spontaneous and bleomycin-induced genomic alterations in the progeny of Drosophila treated males depends on the Msh2 status. DNA fingerprinting analysis.
- Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer.
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