Release-controlling absorption enhancement of enterally administered Ophiopogon japonicus polysaccharide by sodium caprate in rats.
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Summary
The findings indicate that all the SC containing formulations can significantly improve FITC-OJP bioavailability and that the better the balance between the two opposite effects for drug absorption, the more effective absorption enhancement would be obtained.
- Type
- article
- Published
- 2006-11-01
- Cited by
- 27
- References
- 12
- OpenAlex
- https://openalex.org/W2011574055
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:22576413
Keywords
Chemistry, Bioavailability, Chromatography, Absorption (acoustics), Pharmacology
References
- Sodium Caprate Elicits Dilatations in Human Intestinal Tight Junctions and Enhances Drug Absorption by the Paracellular Route
- Synchronized Release of Sulpiride and Sodium Decanoate from HPMC Matrices: A Rational Approach to Enhance Sulpiride Absorption in the Rat Intestine
- Oral Solid Controlled Release Dosage Forms: Role of GI-Mechanical Destructive Forces and Colonic Release in Drug Absorption Under Fasted and Fed Conditions in Humans
- Preparation and properties of fluorescein-labelled dextrans
- Protein release from alginate matrices.
- The importance of intestinal residence time of absorption enhancer on drug absorption and implication on formulative considerations
- Determination of Ophiopogon japonicus polysaccharide in plasma by HPLC with modified postcolumn fluorescence derivatization.
- Physiological mechanism for enhancement of paracellular drug transport.
- Mechanisms of absorption enhancement and tight junction regulation
- Active components of Polysaccharide of Ophiopogon Japonicus on acute myocardial ischemia
- [Isolation, purification and structural analysis of a polysaccharide MDG-1 from Ophiopogon japonicus].
- Integration of secretory and absorptive function.
- Protein release from alginate matrices
Cited by
- Nanocarrier systems for oral drug delivery: do we really need them?
- Long-circulating delivery of bioactive polysaccharide from radix ophiopogonis by PEGylation
- Oral self-nanoemulsifying peptide drug delivery systems: impact of lipase on drug release
- What are parameters affecting Leu-enkephalin loading and release from poly(isobutylcyanoacrylate) nanoparticles coated with thiolated chitosan?
- Injectable long-acting in situ forming systems for Radix Ophiopogonis polysaccharide.
- Poly(ethylene glycol)-radix Ophiopogonis polysaccharide conjugates: preparation, characterization, pharmacokinetics and in vitro bioactivity.
- Antitumor activity of bacterial exopolysaccharides from the endophyte Bacillus amyloliquefaciens sp. isolated from Ophiopogon japonicus
- Biorelevant refinement of the Caco-2 cell culture model to assess efficacy of paracellular permeability enhancers.
- Thiolated polycarbophil/glutathione: Defining its potential as a permeation enhancer for oral drug administration in comparison to sodium caprate
- Safety and efficacy of sodium caprate in promoting oral drug absorption: from in vitro to the clinic.
- Injectable long-acting systems for Radix Ophiopogonis polysaccharide based on mono-PEGylation and in situ formation of a PLGA depot
- Reprint of: Nanocarrier systems for oral drug delivery: do we really need them?
- The optimization of sulfation modification conditions for ophiopogonpolysaccharide based on antiviral activity.
- A sensitive and specific HPGPC-FD method for the study of pharmacokinetics and tissue distribution of Radix Ophiopogonis polysaccharide in rats.
- Hydrophobic mixed solvent induced PLGA-based in situ forming systems for smooth long-lasting delivery of Radix Ophiopogonis polysaccharide in rats
- Delivery of radix ophiopogonis polysaccharide via sucrose acetate isobutyrate-based in situ forming systems alone or combined with its mono-PEGylation
- Perspective: Aggregation-induced emission as an emerging strategy for exploring pharmacokinetics of oral polysaccharides
- Recent advances in polysaccharides from Ophiopogon japonicus and Liriope spicata var. prolifera.
- Delivery of polysaccharides from Ophiopogon japonicus (OJPs) using OJPs/chitosan/whey protein co-assembled nanoparticles to treat defective intestinal epithelial tight junction barrier.
- Pharmacokinetics and Excretion Study of Lycium barbarum Polysaccharides in Rats by FITC-Fluorescence Labeling
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