Molecular therapy of the intervertebral disc
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Summary
This review article will give insight into the current and developing status of treating intervertebral disc degeneration from a molecular standpoint.
- Type
- review
- Published
- 2006-07-12
- Cited by
- 104
- References
- 70
- Access
- Open access
- OpenAlex
- https://openalex.org/W2011570852
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:5680390
Keywords
Intervertebral disc, Medicine, Degeneration (medical), Intervertebral Disc Displacement, Degenerative disc disease
References
- Intradiscal application of hyaluronic acid in the non-human primate lumbar spine: radiological results
- A Novel Rabbit Model of Mild, Reproducible Disc Degeneration by an Anulus Needle Puncture: Correlation Between the Degree of Disc Injury and Radiological and Histological Appearances of Disc Degeneration
- Intradiscal Administration of Osteogenic Protein-1 Increases Intervertebral Disc Height and Proteoglycan Content in the Nucleus Pulposus in Normal Adolescent Rabbits
- Cartilage-derived morphogenetic proteins. New members of the transforming growth factor-beta superfamily predominantly expressed in long bones during human embryonic development.
- Human IL-1Ra gene transfer into human synovial fibroblasts is chondroprotective.
- 1991 Volvo Award in Basic Sciences: Collagen Types Around the Cells of the Intervertebral Disc and Cartilage End Plate: An Immunolocalization Study
- The Effect of Bone Morphogenetic Protein-2 on Rat Intervertebral Disc Cells in Vitro
- In Vivo Growth Factor Treatment of Degenerated Intervertebral Discs
- Intraarticular expression of biologically active interleukin 1-receptor-antagonist protein by ex vivo gene transfer.
- Degeneration and the chemical composition of the human lumbar intervertebral disc
- Age-related changes in expression of transforming growth factor-beta and receptors in cells of intervertebral discs.
- A biological approach to treating disc degeneration: not for today, but maybe for tomorrow
- Bone Morphogenetic Protein-2 Facilitates Expression of Chondrogenic, not Osteogenic, Phenotype of Human Intervertebral Disc Cells
- Intervertebral Disc Autografting in a Bipedal Animal Model
- A Fibronectin Fragment Alters the Metabolism by Rabbit Intervertebral Disc Cells In Vitro
- BMP-2 and CDMP-2: stimulation of chondrocyte production of proteoglycan
- Osteogenic protein-1 enhances matrix replenishment by intervertebral disc cells previously exposed to interleukin-1.
- Biologic strategies for the therapy of intervertebral disc degeneration
- Cost-Effectiveness Analysis of Extended Conservative Therapy Versus Surgical Intervention in the Management of Herniated Lumbar Intervertebral Disc
- Immunolocalization of bone morphogenetic protein and its receptors in degeneration of intervertebral disc.
Cited by
- Comparative Effects of Bone Morphogenetic Proteins and Sox9 Overexpression on Matrix Accumulation by Bovine Anulus Fibrosus Cells: Implications for Anular Repair
- Regenerative treatment strategies in spinal surgery.
- Intercellular Signaling Pathways Active During Intervertebral Disc Growth, Differentiation, and Aging
- Comparative Expression of Matrix-associated Genes and Inflammatory Cytokines-associated Genes According to Disc Degeneration: Analysis of Living Human Nucleus Pulposus
- The effect of capacitively coupled (CC) electrical stimulation on human disc nucleus pulposus cells and the relationship between CC and BMP-7
- Développement de l'ingénierie tissulaire du disque intervertébral : de la physiopathologie aux modèles animaux
- The cellular and molecular biology of the intervertebral disc: A clinician's primer.
- Diversity of intervertebral disc cells: phenotype and function
- Novel Cartilage‐derived Biomimetic Scaffold for Human Nucleus Pulposus Regeneration: a Promising Therapeutic Strategy for Symptomatic Degenerative Disc Diseases
- Prospective study of disc repair with allogeneic chondrocytes presented at the 2012 Joint Spine Section Meeting.
- Studies on the degeneration and regeneration of the intervertebral disc
- Optimisation and validation of a tri-axial bioreactor for nucleus pulposus tissue engineering
- ISSLS Prize Winner: Effect of Link Protein Peptide on Human Intervertebral Disc Cells
- PDGF, bFGF and IGF-I stimulate the proliferation of intervertebral disc cells in vitro via the activation of the ERK and Akt signaling pathways
- Expression of ADAMTS-7 and ADAMTS-12 in the nucleus pulposus during degeneration of rat caudal intervetebral disc.
- Biological treatment for degenerative disc disease: implications for the field of physical medicine and rehabilitation.
- Human nucleus pulposus cells significantly enhanced biological properties in a coculture system with direct cell‐to‐cell contact with autologous mesenchymal stem cells
- Cell Signaling Pathways Related to Pain Receptors in the Degenerated Disk
- Growth factors and platelet-rich plasma: promising biological strategies for early intervertebral disc degeneration
- Delivery systems for the treatment of degenerated intervertebral discs.
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