Effective drug delivery by PEGylated drug conjugates.
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Summary
An update of drug delivery using poly(ethylene glycol) (PEG), that focuses on recent developments in both protein and organic drugs, is presented, that includes applications of high molecular weight PEG prodrug strategies to amino containing drugs.
- Type
- review
- Published
- 2003-02-10
- Cited by
- 796
- References
- 119
- OpenAlex
- https://openalex.org/W2011370547
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:20821836
Keywords
Prodrug, PEG ratio, PEGylation, Chemistry, Drug delivery
References
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- Review: Poly(Ethylene Glycol)s with Reactive Endgroups. II. Practical Consideration for the Preparation of Protein-PEG Conjugates
- THE CHEMISTRY AND PHARMACOLOGY OF TAXOL® AND ITS DERIVATIVES
- The pharmacology of prodrugs of 5-fluorouracil and 1-beta-D-arabinofuranosylcytosine.
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- Cellular Uptake Mechanism of Amino Acid Ester Prodrugs in Caco-2/hPEPT1 Cells Overexpressing a Human Peptide Transporter
- Carboxyalkylated Histidine Is a pH-Dependent Product of Pegylation with SC-PEG
- Relationship of effective molecular size to systemic clearance in rats of recombinant interleukin-2 chemically modified with water-soluble polymers.
- Amino Acids and Peptides: XXXII: A Bifunctional Poly(Ethylene Glycol) Hybrid of Fibronectin-Related Peptides
Cited by
- Factor VIII efficient and specific non-covalent binding to PEGylated liposomes enables prolongation of its circulation time and haemostatic efficacy
- Drug design using the example of the complement system inhibitors' development.
- Site-specific PEGylation of protein disulfide bonds using a three-carbon bridge.
- Site-specific modification and PEGylation of pharmaceutical proteins mediated by transglutaminase.
- Tethering polypeptides through bifunctional PEG cross‐linking agents to probe protein function: Application to ATP synthase
- The conformation of the poly(ethylene glycol) chain in mono-PEGylated lysozyme and mono-PEGylated human growth hormone.
- Insulin complexes with PEGylated basic oligopeptides.
- Insertion of flexible neural probes using rigid stiffeners attached with biodissolvable adhesive.
- Poly(ethylene glycol)-poly(lactic-co-glycolic acid) based thermosensitive injectable hydrogels for biomedical applications.
- Free paclitaxel loaded PEGylated-paclitaxel nanoparticles: preparation and comparison with other paclitaxel systems in vitro and in vivo.
- Challenges in SN38 drug delivery: current success and future directions
- Covalent Organic Frameworks: From Materials Design to Biomedical Application
- Exploring a "Nature-Inspired" Strategy for Enhancing the Pharmacology of Small Molecules: Towards the Development of Next Generation Anti-Infectives.
- Modeling Small Molecule Elution From a Hydrogel using a Microfluidic Technique
- Drug delivery : creating opportunities from pharmacokinetic challenges / Josias Hendrik Hamman
- Oral Delivery of Peptide Drugs
- Generierung und In vitro Charakterisierung rekombinanter bispezifischer CD3 x NCAM und CD3 x VEGFR-2 Antikörper für die Neuroblastomtherapie
- FUNCTIONAL PHOSPHORYLCHOLINE POLYMERS: PRODRUGS AND BIOMATERIALS
- PEG-interferon conjugates: effects of length and structure of linker.
- Design and Synthesis of Novel PEG-conjugated 20(S)-Camptothecin Sulfonylamidine Derivatives with Potent in vitro Antitumor Activity via Cu-Catalyzed Three-Component Reaction
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