Drug design using the example of the complement system inhibitors' development.
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Summary
The main approaches of drug design, ranging from screening and modification of natural products to structure-based ligand design, on the basis of complement inhibitors' creation are illustrated.
- Type
- dissertation
- Published
- 2005-11-15
- Cited by
- 23
- References
- 49
- OpenAlex
- https://openalex.org/W16257376
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:1328622
Keywords
Humanities, Political science, Art
References
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- A systems science view on cell death signalling
- Complement-targeted therapeutics
- Design and development of TT30, a novel C3d-targeted C3/C5 convertase inhibitor for treatment of human complement alternative pathway-mediated diseases.
- Therapeutic potential of complement modulation
- Structure of C3c in complex with compstatin reveals a new mechanism of complement inhibition
- Selective inhibition of the interaction of C1q with immunoglobulins and the classical pathway of complement activation by steroids and triterpenoids sulfates.
- Structure of Compstatin in Complex with Complement Component C3c Reveals a New Mechanism of Complement Inhibition*
- Neuronal death in Alzheimer’s disease and therapeutic opportunities
- Synthesis and classical pathway Complement inhibitory activity of C7-functionalized filifolinol derivatives, inspired in K-76 COOH.
- Search for invisible binding sites of low-molecular-weight compounds on protein molecules and prediction of inhibitory activity
- Complement inactivating proteins and intraspecies venom variation in Crotalus oreganus helleri.
- LOC387715/HTRA1 and Complement Factor H Variants in Patients with Age-Related Macular Degeneration Seen at the Mayo Clinic
- Impact of the complement cascade on posttraumatic cartilage inflammation and degradation.
- C1, MBL-MASPs and C1-inhibitor: novel approaches for targeting complement-mediated inflammation.
- mediated diseases - pathway convertase inhibitor for treatment of human complement alternative Design and development of TT30, a novel C3d-targeted C3/C5
- The role of complement in the immunologic microenvironment of tumor cells: Potential therapeutic targets
- Exploration cristallographique de certains trésors cachés de la défense innée
- Janus face of complement-driven neutrophil activation during sepsis.
- Molecular targeted study in tumors: From western medicine to active ingredients of traditional Chinese medicine.
- Inhibition du complément pour régénération nerveuse améliorée
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