Reactive oxygen species in cancer cells: live by the sword, die by the sword.
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Summary
Evidence suggests that transformed cells use ROS signals to drive proliferation and other events required for tumor progression, making them vulnerable to chemotherapeutic agents that further augment ROS generation or that weaken antioxidant defenses of the cell.
- Type
- letter
- Published
- 2006-09-01
- Cited by
- 1,249
- References
- 8
- Access
- Open access
- OpenAlex
- https://openalex.org/W2011006339
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:40034361
Keywords
Reactive oxygen species, Oxidative stress, SWORD, Cell biology, Biology
References
- Production of large amounts of hydrogen peroxide by human tumor cells.
- The proteasome inhibitor bortezomib induces apoptosis in mantle-cell lymphoma through generation of ROS and Noxa activation independent of p53 status.
- Thioredoxin Reductase 1 Deficiency Reverses Tumor Phenotype and Tumorigenicity of Lung Carcinoma Cells*
- A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine
- Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines.
- Distinct Roles of Thioredoxin in the Cytoplasm and in the Nucleus
- mtDNA mutations increase tumorigenicity in prostate cancer.
- Synergistic Effect of Histone Deacetylase Inhibitors FK228 and m-Carboxycinnamic Acid Bis-Hydroxamide with Proteasome Inhibitors PSI and PS-341 against Gastrointestinal Adenocarcinoma Cells
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- In vitro pro-oxidant action of Methotrexate in presence of white light.
- Dihydroartemisinin Enhances Apo2L/TRAIL-Mediated Apoptosis in Pancreatic Cancer Cells via ROS-Mediated Up-Regulation of Death Receptor 5
- Ascorbic acid in cancer chemoprevention: translational perspectives and efficacy.
- Antitumor effect of Japanese apricot extract (MK615) on human cancer cells in vitro and in vivo through a reactive oxygen species-dependent mechanism.
- Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles’ heel?
- The small molecule C-6 is selectively cytotoxic against breast cancer cells and its biological action is characterized by mitochondrial defects and endoplasmic reticulum stress
- 2-deoxy-D-Glucose Synergizes with Doxorubicin or L-Buthionine Sulfoximine to Reduce Adhesion and Migration of Breast Cancer Cells.
- Cyclin-dependent kinase inhibitor dinaciclib potently synergizes with cisplatin in preclinical models of ovarian cancer
- Mangrove dolabrane‐type of diterpenes tagalsins suppresses tumor growth via ROS‐mediated apoptosis and ATM/ATR–Chk1/Chk2‐regulated cell cycle arrest
- Synthesis and Antileukemic Activities of C1-C10-Modified Parthenolide Analogues
- Targeting thiamine-dependent enzymes for metabolic therapies in oral squamous cell carcinoma?
- Cystine/glutamate antiporter blockage induces myelin degeneration
- Amitriptyline induces mitophagy that precedes apoptosis in human HepG2 cells
- Transcriptome and proteome profiling reveals stress-induced expression signatures of imiquimod-treated Tasmanian devil facial tumor disease (DFTD) cells
- Sensitivity to and functional effects of tricyclic agents on glioma: an immunohistochemical and in vitro study
- Novel Functions of Cetuximab in EGFR-targeted Therapy: Radiosensitization, Glycolysis Inhibition, and Cellular Redox Status Regulation
- Medicinal Uses of Chlorophyll: a critical overview
- Insights into Toxin Binding to Tubulin as a Potential Trigger in Parkinson's Disease Using Molecular Modeling
- REACTIVE OXYGEN SPECIES AND P21 WAF1/CIP1 ARE BOTH ESSENTIAL FOR
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