PLGA nanoparticles prepared by nanoprecipitation: drug loading and release studies of a water soluble drug.
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Summary
It was found that an aqueous phase pH of 9.3, replacement of procaine hydrochloride with procaine dihydrate and the incorporation of PMMA-MA, lauric and caprylic acid into the formulation could enhance drug incorporation efficiency without the size, morphology and nanoparticle recovery being adversely influenced.
- Type
- article
- Published
- 1999-02-01
- Cited by
- 994
- References
- 21
- OpenAlex
- https://openalex.org/W2009974403
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11026717
Keywords
Nanoparticle, Chemistry, Procaine Hydrochloride, Dispersity, Lauric acid
References
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- Preparation of neurotensin analogue-containing poly(dl-lactic acid) microspheres formed by oil-in-water solvent evaporation.
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- The colloidal properties of surfactant-free biodegradable nanospheres from poly(β-malic acid-co-benzyl malate)s and poly(lactic acid-co-glycolide)
- Poly (DL-lactide) nanocapsules containing diclofenac: I. Formulation and stability study
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- A new in vitro technique for the evaluation of drug release profile from colloidal carriers - ultrafiltration technique at low pressure
- Comparative study of the association of itraconazole with colloidal drug carriers
- Optimized preparation of poly d,l (lactic-glycolic) microspheres and nanoparticles for oral administration
- Polylactic acid microspheres containing quinidine base and quinidine sulphate prepared by the solvent evaporation technique. I. Methods and morphology.
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- Primaquine-loaded poly(lactide) nanoparticles : physicochemical study and acute tolerance in mice
- Drug loading of biodegradable nanoparticles for site specific drug delivery.
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- Encapsulation and sustained release from biodegradable microcapsules made by emulsification/freeze drying and spray/freeze drying.
- Polyethylene sebacate-doxorubicin nanoparticles for hepatic targeting.
- Characterization of rhodamine loaded PEG-g-PLA nanoparticles (NPs): effect of poly(ethylene glycol) grafting density.
- The manufacturing techniques of drug-loaded polymeric nanoparticles from preformed polymers
- Poly(lactic-co-glycolic acid) matrix incorporated with nisin as a novel antimicrobial biomaterial
- Development of quercetin nanoformulation and in vivo evaluation using streptozotocin induced diabetic rat model
- Recombinant L7/L12 protein entrapping PLGA (poly lactide-co-glycolide) micro particles protect BALB/c mice against the virulent B. abortus 544 infection.
- Solid lipid nanoparticles surface modified with anti-Contactin-2 or anti-Neurofascin for brain-targeted delivery of medicines
- Colloidal Particles as Antimicrobial Carrier Systems
- In vivo β-catenin attenuation by the integrin α5-targeting nano-delivery strategy suppresses triple negative breast cancer stemness and metastasis.
- Particles from preformed polymers as carriers for drug delivery
- Formulation and process engineering of freeze-dried orally disintegrating tablets
- Influence of process and formulation parameters on the formation of submicron particles by solvent displacement and emulsification-diffusion methods critical comparison.
- Gelatin nanoparticles produced by a simple W/O emulsion as delivery system for methotrexate
- Antibacterial activity of doxycycline-loaded nanoparticles.
- Processing of biodegradable polymer microparticles for sustained drug delivery.
- Development of multifunctional polymeric nanoparticles by nano-emulsion templating as advanced nanocarriers targeting the blood-brain barrier
- Preparation and in-vitro Evaluation of Poly--Caprolactone Nanoparticles Containing Atorvastation Calcium
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