In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector
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Summary
The ability of HIV-based viral vectors to deliver genes in vivo into nondividing cells could increase the applicability of retroviral vectors in human gene therapy.
- Type
- article
- Published
- 1996-04-12
- Cited by
- 5,150
- References
- 71
- OpenAlex
- https://openalex.org/W2009761723
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:18997464
Keywords
Transduction (biophysics), Biology, Viral vector, Heterologous, Genetic enhancement
References
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- Identification of a sequence required for efficient packaging of human immunodeficiency virus type 1 RNA into virions
- Use of retroviral vectors for gene transfer and expression.
- Passage through mitosis is required for oncoretroviruses but not for the human immunodeficiency virus
- Packaging of human immunodeficiency virus type 1 RNA requires cis-acting sequences outside the 5' leader region
- Purine and pyrimidine metabolism in human T lymphocytes. Regulation of deoxyribonucleotide metabolism.
- Restriction and enhancement of human immunodeficiency virus type 1 replication by modulation of intracellular deoxynucleoside triphosphate pools
- Analysis in human immunodeficiency virus type 1 vectors of cis-acting sequences that affect gene transfer into human lymphocytes
- Mutations of RNA and protein sequences involved in human immunodeficiency virus type 1 packaging result in production of noninfectious virus
- Packaging system for rapid production of murine leukemia virus vectors with variable tropism
- Construction and use of a human immunodeficiency virus vector for analysis of virus infectivity
- Human immunodeficiency virus vectors for inducible expression of foreign genes
- Productive HIV‐1 infection of macrophages restricted to the cell fraction with proliferative capacity.
- Human immunodeficiency virus type 1 integrase mutants retain in vitro integrase activity yet fail to integrate viral DNA efficiently during infection
- Gene transfer into human lymphocytes by a defective human immunodeficiency virus type 1 vector
- Mutational analysis of cis-acting packaging signals in human immunodeficiency virus type 1 RNA
- High-efficiency transformation of mammalian cells by plasmid DNA.
Cited by
- HIV-based vectors. Preparation and use.
- Efficient transduction of hematopoietic stem cells and its potential for gene correction of hematopoietic diseases.
- Development and application of non-integrating lentiviral vectors for gene therapy
- Human immunodeficiency virus type 2 preintegration complexes: activities in vitro and response to inhibitors
- Strategies for achieving multiple layers of selectivity in gene therapy.
- Lentiviruses as gene transfer agents for delivery to non-dividing cells.
- Intrinsic Human Immunodeficiency Virus Type 1 Resistance of Hematopoietic Stem Cells Despite Coreceptor Expression
- Retroviral vectors for cancer gene therapy.
- β-Galactosidase marker genes to tag and track human hematopoietic cells
- HIV-1 Vpr: G2 cell cycle arrest, macrophages and nuclear transport.
- Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef- and Vpu-inhibitable manner.
- Lentivirus Vector Mobilization and Spread by Human Immunodeficiency Virus
- Stable Transduction with Lentiviral Vectors and Amplification of Immature Hematopoietic Progenitors from Cord Blood of Preterm Human Fetuses
- Recombinant proteins for neurodegenerative diseases: the delivery issue.
- Transcriptional Silencing of Retroviral Vectors.
- Design of an HIV-1 lentiviral-based gene-trap vector to detect developmentally regulated genes in mammalian cells
- Lentiviral vectors for gene therapy of HIV-induced disease.
- Gene therapy for retinal and choroidal diseases
- Effects of Varying Sequence Similarity on the Frequency of Repeat Deletion during Reverse Transcription of a Human Immunodeficiency Virus Type 1 Vector
- Lentiviral vectors pseudotyped with a modified RD114 envelope glycoprotein show increased stability in sera and augmented transduction of primary lymphocytes and CD34+ cells derived from human and nonhuman primates.
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