Gene transfer into human lymphocytes by a defective human immunodeficiency virus type 1 vector
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Summary
It is reported that packaging-defective proviruses can provide trans-acting viral elements required for the transfer of a HIV-1 vector to Jurkat human lymphocytes and that the long terminal repeats and the immediate flanking viral sequences are sufficient for packaging, reverse transcription, and integration.
- Type
- article
- Published
- 1991-01-01
- Cited by
- 156
- References
- 28
- Access
- Open access
- OpenAlex
- https://openalex.org/W1939899968
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:30178781
Keywords
Biology, Long terminal repeat, Virology, Vector (molecular biology), Viral vector
References
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- Gene transfer into primates and prospects for gene therapy in humans.
- Evidence that the packaging signal of Moloney murine leukemia virus extends into the gag region
- Persistent productive infection of human glial cells by human immunodeficiency virus (HIV) and by infectious molecular clones of HIV
- High-efficiency transformation of mammalian cells by plasmid DNA.
- Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS.
- Complete Nucleotide Sequences of Functional Clones of the AIDS Virus
- Retrovirus transfer of a bacterial gene into mouse haematopoietic progenitor cells
- Expanded HIV-1 cellular tropism by phenotypic mixing with murine endogenous retroviruses.
- Detection of specific sequences among DNA fragments separated by gel electrophoresis.
- Role of the HTLV-III/LAV envelope in syncytium formation and cytopathicity
- Construction and applications of a highly transmissible murine retrovirus shuttle vector.
- Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus.
- Selective tropism of lymphadenopathy associated virus (LAV) for helper-inducer T lymphocytes.
- Structure, replication, and recombination of retrovirus genomes: some unifying hypotheses.
- Immunologic aspects of the acquired immunodeficiency syndrome and male homosexuality.
Cited by
- Lentiviruses as gene transfer agents for delivery to non-dividing cells.
- NMR structure of stem-loop SL2 of the HIV-1 psi RNA packaging signal reveals a novel A-U-A base-triple platform.
- Lentivirus Vector Mobilization and Spread by Human Immunodeficiency Virus
- Gene therapy for retinal and choroidal diseases
- A Synthetic Rev-Independent Bovine Immunodeficiency Virus-Based Packaging Construct
- AIDS and HIV infection.
- Activity Profiles & Mechanisms of Resistance of 3'-Azido-2',3'-Dideoxynucleoside Analog Reverse Transcriptase Inhibitors of HIV-1
- Dévelappement de vecteurs lentiviraux non-intergratifs en vue du transfert de gènes dans le système nerveux central.
- Transfert de genes a potentiel therapeutique dans des modeles de la maladie de huntington developpes chez le rat
- Generation of HIV-1 derived lentiviral vectors.
- Principles of Gene Manipulation and Genomics
- Molecular and Cell Biology of Human Gene Therapeutics
- Expansion and genetic modification of human natural killer cells for adoptive immunotherapy of cancer
- Development of lentiviral vectors for gene therapy for human diseases.
- HIV RNA packaging and lentivirus-based vectors.
- Transgene expression and RNA interference in embryonic stem cells.
- A human immunodeficiency virus type 1 (HIV-1)-based retroviral vector system utilizing stable HIV-1 packaging cell lines
- Retroviral and lentiviral gene therapy for autoimmune disease.
- Truncation of the human immunodeficiency virus type 1 envelope glycoprotein allows efficient pseudotyping of Moloney murine leukemia virus particles and gene transfer into CD4+ cells
- Alternative approaches for the application of ribozymes as gene therapies for retroviral infections.
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