Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches
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Summary
The extracellular patch clamp method, which first allowed the detection of single channel currents in biological membranes, has been further refined to enable higher current resolution, direct membrane patch potential control, and physical isolation of membrane patches.
- Type
- article
- Published
- 1981-07-30
- Cited by
- 8,130
- References
- 24
- OpenAlex
- https://openalex.org/W2009667219
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:12014433
Keywords
Patch clamp, Current (fluid), Membrane, Resolution (logic), Current clamp
References
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- Identification of a voltage- and calcium-dependent non-selective cation channel in cultured adult and fetal human nasal epithelial cells
- Patch-clamp studies of K+ and Cl− channel currents in canine pancreatic acinar cells
- Characterization of an outward K+ current in freshly dispersed cerebral arterial muscle cells
- Measurement of Ca2+-release-dependent inward current reveals two distinct components of Ca2+ release from sarcoplasmic reticulum in guinea-pig atrial myocytes
- Voltage-gated K+ channels in the mouse interleukin 3-dependent cell line, FDC-P2
- Manual whole-cell patch-clamping of the HERG cardiac K+ channel.
- On the mechanism of activation of muscarinic K+ channels by adenosine in isolated atrial cells: involvement of GTP-binding proteins
- Maxi K+ channels in leaky epithelia are regulated by intracellular Ca2+, pH and membrane potential
- Involvement of calcium in calcium-current inactivation in smooth muscle cells from rat vas deferens
- Effects of toxin II from the scorpion Androctonus australis Hector on sodium current in neuroblastoma cells and their modulation by oleic acid
- Temperature-dependent subconducting states and kinetics of deltamethrin-modified sodium channels of neuroblastoma cells
- Tetrodotoxin differentially blocks peak and steady-state sodium channel currents in early embryonic chick ventricular myocytes
- Bicuculline and picrotoxin block γ-aminobutryic acid-gated Cl− conductance by different mechanisms
- Simultaneous recording of cell volume, membrane current and membrane potential: effect of hypotonic shock
- Reciprocal effects of Ca2+ and Mg-ATP on the ‘run-down’ of the K+ channels in opossum kidney cells
- Effects of a protein phosphatase inhibitor, okadaic acid, on membrane currents of isolated guinea-pig cardiac myocytes
- Subtypes of dorsal root ganglion neurons based on different inward currents as measured by whole-cell voltage clamp
- Nuclear patch-clamp recording from inositol 1,4,5-trisphosphate receptors.
- The inhibitory effect of copper ions on lymphocyte Kv1.3 potassium channels.
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