Expression of myostatin pro domain results in muscular transgenic mice
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Summary
The results of this study suggest that the over‐expression of myostatin pro domain may provide an alternative to mystatin knockouts as a means of increasing muscle mass in other mammals.
- Type
- article
- Published
- 2001-11-01
- Cited by
- 194
- References
- 39
- Access
- Open access
- OpenAlex
- https://openalex.org/W2009324447
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:872178
Keywords
Myostatin, Biology, Transgene, Muscle hypertrophy, Internal medicine
References
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- Fast skeletal muscle myosin light chains 1 and 3 are produced from a single gene by a combined process of differential RNA transcription and splicing.
- Selection of efficient cleavage sites in target RNAs by using a ribozyme expression library
- Simple RNA enzymes with new and highly specific endoribonuclease activities
- Efficient and specific ribozyme-mediated reduction of bovine alpha-lactalbumin expression in double transgenic mice.
- Dominant negative myostatin produces hypertrophy without hyperplasia in muscle
- Transgenic cattle resulting from biopsied embryos: expression of c-ski in a transgenic calf.
- Double muscling in cattle: a review
- The pro domain of pre-pro-transforming growth factor beta 1 when independently expressed is a functional binding protein for the mature growth factor.
- Multi-unit anti-BCR-ABL ribozyme therapy in chronic myelogenous leukemia.
- A deletion in the bovine myostatin gene causes the double–muscled phenotype in cattle
- Multitarget-ribozyme directed to cleave at up to nine highly conserved HIV-1 env RNA regions inhibits HIV-1 replication--potential effectiveness against most presently sequenced HIV-1 isolates.
- Myosin light chain enhancer activates muscle-specific, developmentally regulated gene expression in transgenic mice.
- Ribozyme-mediated attenuation of pancreatic beta-cell glucokinase expression in transgenic mice results in impaired glucose-induced insulin secretion.
- Growth factors controlling muscle development.
Cited by
- Effects of the myostatin F94L substitution on beef traits.
- Enhanced skeletal muscle for effective glucose homeostasis.
- Targeted mutations in myostatin by zinc-finger nucleases result in double-muscled phenotype in Meishan pigs
- Développement et caractérisation de deux modèles murins présentant un phénotype hypermusclé
- Effects of maternal immunization against myostatin on skeletal muscle mass of offspring in mice
- Expression of Lysostaphin in Milk of Transgenic Mice Affects the Growth of Neonates
- Invalidation du gène Gasp1 et étude de sa fonction chez la souris
- HIGH-YIELD PRODUCTION OF BIOACTIVE FLATFISH ( PARALICHTHYS OLIVACEUS ) MYOSTATIN-1 PRODOMAIN IN ESCHERICHIA COLI
- Regulation of the Structure and Function of Skeletal Muscle and Tendon by Myostatin.
- Animal Transgenesis and Cloning
- Regulation of the Myostatin Protein in Overload-Induced Hypertrophied Rat Skeletal Muscle
- Etude des conséquences fonctionnelles de l’inhibition de la myostatine par GASP-1 au cours du développement musculaire :
- Animal productivity and genetic diversity: cloned and transgenic animals - animal agriculture's future through biotechnology, Part 8.
- Myostatin and tgf-beta function in the regulation of myogenesis in rainbow trout (Oncorhynchus mykiss), a basal teleost
- The influence of sex hormones on cardiac and skeletal muscle function in the MDX mouse model of Duchenne Muscular Dystrophy
- Papel de la miostatina en la regulación de la hematopoyesis
- The decrease in mature myostatin protein in male skeletal muscle is developmentally regulated by growth hormone
- The intraovarian cellular origins of GDF9 and BMP15 in the mouse and aspects of their biological properties
- Voimaharjoittelun ja proteiinisupplementaation vaikutus myostatiinin ja siihen liittyvien geenien ilmentymiseen nuorilla ja vanhoilla miehillä
- Over-Expression of Porcine Myostatin Missense Mutant Leads to A Gender Difference in Skeletal Muscle Growth between Transgenic Male and Female Mice
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