Neurovascular pathways to neurodegeneration in Alzheimer’s disease and other disorders
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Summary
Mechanisms of BBB dysfunction in neurodegenerative disorders, notably Alzheimer's disease, are examined, and therapeutic opportunities relating to these neurovascular deficits are highlighted.
- Type
- review
- Published
- 2011-11-03
- Cited by
- 2,847
- References
- 249
- OpenAlex
- https://openalex.org/W2006035554
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:12275559
Keywords
Neurodegeneration, Neurovascular bundle, Neuroscience, Blood–brain barrier, Cerebral blood flow
References
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- Mitochondria: the missing link between preconditioning and neuroprotection.
- Plaque‐associated disruption of CSF and plasma amyloid‐β (Aβ) equilibrium in a mouse model of Alzheimer's disease
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- Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration
Cited by
- Cerebral Blood Flow Measured by Arterial Spin Labeling MRI as a Preclinical Marker of Alzheimer’s Disease
- The vascular factor in Alzheimer's disease: a study in Golgi technique and electron microscopy.
- Death by a Thousand Cuts in Alzheimer’s Disease: Hypoxia—The Prodrome
- The astrocytic contribution to neurovascular coupling--still more questions than answers?
- Expression of VEGF and Flk-1 and Flt-1 Receptors during Blood-Brain Barrier (BBB) Impairment Following Phoneutria nigriventer Spider Venom Exposure
- Microglial CR3 activation triggers long-term synaptic depression in the hippocampus via NADPH oxidase.
- The low-density lipoprotein receptor-related protein 1 and amyloid-β clearance in Alzheimer’s disease
- ABC transporter regulation by signaling at the blood-brain barrier: relevance to pharmacology.
- Cerebrovascular and blood–brain barrier impairments in Huntington's disease: Potential implications for its pathophysiology
- Hypertension enhances Aβ-induced neurovascular dysfunction, promotes β-secretase activity, and leads to amyloidogenic processing of APP
- Induction of Genes Expressed in Endothelial Cells of the Corpus Callosum in the Chronic Cerebral Hypoperfusion Rat Model
- Introduction to special issue: Neurovascular aging—A driving force for neurological dysfunction in stroke and neurodegenerative diseases
- Insight of brain degenerative protein modifications in the pathology of neurodegeneration and dementia by proteomic profiling
- The Eye As a Biomarker for Alzheimer's Disease
- Influence of Circulating Endothelin-1 and Asymmetric Dimethylarginine on Whole Brain Circulation Time in Multiple Sclerosis
- Circulating progenitor cells correlate with memory, posterior cortical thickness and hippocampal perfusion
- An MRI measure of degenerative and cerebrovascular pathology in Alzheimer disease
- Cardiovascular disease risk is associated with middle cerebral artery blood flow velocity in older adults
- Imaging Vascular Disease and Amyloid in the Aging Brain: Implications for Treatment
- PHYSIOLOGY AND PATHOPHYSIOLOGY OF THE BLOOD BRAIN BARRIER
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