Construction of a general human chromosome jumping library, with application to cystic fibrosis.
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Summary
A general human chromosome jumping library was constructed that allows the cloning of DNA sequences approximately 100 kilobases away from any starting point in genomic DNA, and should now be applicable to any genetic locus for which a closely linked DNA marker is available.
- Type
- article
- Published
- 1987-02-27
- Cited by
- 183
- References
- 45
- OpenAlex
- https://openalex.org/W2004928211
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:238044
Keywords
Genetics, Biology, genomic DNA, Locus (genetics), Genomic library
References
- A cosmid vector that facilitates restriction enzyme mapping.
- The synthesis and cloning of two tyrosine suppressor tRNA genes with altered promoter sequences.
- Linkage of cystic fibrosis to two tightly linked DNA markers: joint report from a collaborative study.
- Construction of a genetic linkage map in man using restriction fragment length polymorphisms.
- Reverse genetics and human disease.
- Electrophoretic separations of large DNA molecules by periodic inversion of the electric field.
- Purification of genomic sequences from bacteriophage libraries by recombination and selection in vivo.
- Solution of a Protein Crystal Structure with a Model Obtained from NMR Interproton Distance Restraints
- Construction and use of human chromosome jumping libraries from NotI-digested DNA
- A polymorphic DNA marker linked to cystic fibrosis is located on chromosome 7
- The human met oncogene is related to the tyrosine kinase oncogenes
- Packaging recombinant DNA molecules into bacteriophage particles in vitro.
- A highly polymorphic DNA marker linked to adult polycystic kidney disease on chromosome 16
- A closely linked genetic marker for cystic fibrosis
- Separation of yeast chromosome-sized DNAs by pulsed field gradient gel electrophoresis.
- Localization of cystic fibrosis locus to human chromosome 7cen–q22
- Separation of chromosomal DNA molecules from yeast by orthogonal-field-alternation gel electrophoresis.
- Restriction fragment length polymorphisms: Finding the defective gene
- Hopping along the chromosome.
- Fractionation of large mammalian DNA restriction fragments using vertical pulsed-field gradient gel electrophoresis
Cited by
- A class I jumping clone places the HLA-G gene approximately 100 kilobases from HLA-H within the HLA-A subregion of the human MHC.
- Heterogeneity of genetic alterations in primary human breast tumors.
- Short tandem repeats and genetic variation.
- A molecular genetic approach to gld "autoimmune" disease.
- Scientific advances in cystic fibrosis.
- Isolation of additional polymorphic clones from the cystic fibrosis region, using chromosome jumping from D7S8.
- Biochemical and molecular genetics of cystic fibrosis.
- Physical localization of two DNA markers closely linked to the cystic fibrosis locus by pulsed-field gel electrophoresis.
- Sizing of the human T cell receptor alpha locus and detection of a large deletion in the Molt-4 cell line.
- Detection of a NotI polymorphism with the pmetH probe by pulsed-field gel electrophoresis.
- The Three-Dimensional Structure of the Cystic Fibrosis Locus: A Dissertation
- Bacterial genes and genome dynamics in the environment
- Construction of Chromosome Jumping and Linking Libraries in E. coli
- Huntington’s Disease
- Incorporating genomics into the toolkit of nematology.
- Advances in Human Genetics
- The search for the cystic fibrosis gene.
- Construction and use of chromosome jumping libraries.
- Choroideremia and deafness with stapes fixation: a contiguous gene deletion syndrome in Xq21.
- An extended long-range restriction map of the human sex-determining region on Yp, including ZFY, finds marked homology on Xp and no detectable Y sequences in an XX male.
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