SOX2 gene amplification and protein overexpression are associated with better outcome in squamous cell lung cancer
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Summary
High SOX2 expression levels proved to be a marker for prolonged overall survival among patients with squamous cell carcinomas and adenocarcinomas of the lung and are associated with indicators of favorable prognosis.
- Type
- article
- Published
- 2011-07-01
- Cited by
- 192
- References
- 31
- Access
- Open access
- OpenAlex
- https://openalex.org/W2004099683
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24289479
Keywords
SOX2, Biology, Immunohistochemistry, Pathology, Lung cancer
References
- SOX2 is highly expressed in squamous cell carcinomas of the gastrointestinal tract.
- SOX2 amplification is a common event in squamous cell carcinomas of different organ sites.
- Expression of the embryonic stem cell marker SOX2 in early-stage breast carcinoma
- Sox2 is important for two crucial processes in lung development: branching morphogenesis and epithelial cell differentiation.
- SOX2 PROTEIN EXPRESSION IS AN INDEPENDENT POOR PROGNOSTIC INDICATOR IN STAGE I LUNG ADENOCARCINOMA
- Chromosomal abnormalities in cancer.
- Clinical Significance of TTF-1 Protein Expression and TTF-1 Gene Amplification in Lung Adenocarcinoma
- SOX2 in squamous cell carcinoma: Amplifying a pleiotropic oncogene along carcinogenesis
- SOX2 in Gastric Carcinoma, but not Hath1, is Related to Patients’ Clinicopathological Features and Prognosis
- Evidence That SOX2 Overexpression Is Oncogenic in the Lung
- Lineage dependency and lineage-survival oncogenes in human cancer
- Recurrent copy number gain of transcription factor SOX2 and corresponding high protein expression in oral squamous cell carcinoma
- Sox2 Expression in Pulmonary Non-small Cell and Neuroendocrine Carcinomas
- Progressive 3q amplification consistently targets SOX2 in preinvasive squamous lung cancer.
- Pairing SOX off: with partners in the regulation of embryonic development.
- TTF1 expression in non‐small cell lung carcinoma: association with TTF1 gene amplification and improved survival
- Genomic profiling identifies TITF1 as a lineage-specific oncogene amplified in lung cancer
- Functional Evidence that the Self-Renewal Gene NANOG Regulates Human Tumor Development
- Gene amplification in cancer.
- The Increasing Complexity of the Cancer Stem Cell Paradigm
Cited by
- Quantification of protein expression in cells and cellular subcompartments on immunohistochemical sections using a computer supported image analysis system.
- SOX2 Expression and Prognostic Significance in Ovarian Carcinoma
- Autologous anti-SOX2 antibody responses reflect intensity but not frequency of antigen expression in small cell lung cancer
- SOX2 expression is associated with FGFR fusion genes and predicts favorable outcome in lung squamous cell carcinomas
- 分子靶向治疗在肺鳞癌中的研究进展
- The role of SOX2 in small cell lung cancer, lung adenocarcinoma and squamous cell carcinoma of the lung.
- Translationale Forschung und Diagnostik beim Lungenkarzinom
- Molecular pathology of lung cancer
- The prognostic value of whole blood SOX2, NANOG and OCT4 mRNA expression in advanced small-cell lung cancer
- Overexpression of SOX2 Is Associated with Better Overall Survival in Squamous Cell Lung Cancer Patients Treated with Adjuvant Radiotherapy
- 肺鳞癌靶向治疗研究现状
- Pulmonary adenocarcinoma: A renewed entity in 2011
- Somatic copy number alterations by whole‐exome sequencing implicates YWHAZ and PTK2 in castration‐resistant prostate cancer
- Association of OCT4, SOX2, and NANOG expression with oral squamous cell carcinoma progression.
- Loss of SOX2 expression induces cell motility via vimentin up‐regulation and is an unfavorable risk factor for survival of head and neck squamous cell carcinoma
- The role of SOX-2 on the survival of patients with non-small cell lung cancer.
- Clinicopathological significance of cancer stem-like cell markers in high-grade neuroendocrine carcinoma of the lung
- Silencing SOX2 Expression by RNA Interference Inhibits Proliferation, Invasion and Metastasis, and Induces Apoptosis through MAP4K4/JNK Signaling Pathway in Human Laryngeal Cancer TU212 Cells
- Squamous-cell carcinoma of the lungs: is it really so different?
- Expression of the pluripotency markers Oct3/4, Nanog and Sox2 in human breast cancer cell lines.
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