Applications of peptide nucleic acids (PNAs) and locked nucleic acids (LNAs) in biosensor development
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Summary
This contribution is a critical review of the current state of the art concerning the use of nucleic acid analogues, in particular peptide nucleic acids (PNA) and locked nuclei acids (LNA), for the development of high-performance affinity biosensors.
- Type
- review
- Published
- 2012-02-02
- Cited by
- 119
- References
- 129
- OpenAlex
- https://openalex.org/W2004096017
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:39789222
Keywords
Nucleic acid, Biosensor, Peptide nucleic acid, Locked nucleic acid, DNA
References
- Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase.
- Novel method for high throughput DNA methylation marker evaluation using PNA-probe library hybridization and MALDI-TOF detection
- Enhanced recognition of single-base mismatch using locked nucleic acid-integrated hairpin DNA probes revealed by atomic force microscopy nanolithography.
- Nucleic acid-based fluorescent probes and their analytical potential
- Introduction to microarray technology.
- Silicon nanowire biosensor for ultrasensitive and label-free direct detection of miRNAs.
- Recognition Receptors in Biosensors
- Self-assembly of PNA-encoded peptides into microarrays.
- Electrochemical Biosensors: Recommended Definitions and Classification
- Evaluation of locked nucleic acids for signal enhancement of oligonucleotide probes for microalgae immobilised on solid surfaces
- Cannabinoid receptor gene detection by electrochemical genosensor
- Label-free detection of DNA mutations by SPR: application to the early detection of inherited breast cancer
- A novel thrombin binding aptamer containing a G-LNA residue.
- Thermodynamics of sequence-specific binding of PNA to DNA.
- Comparison of the NMR Spectroscopy Solution Structures of Pyranosyl‐RNA and Its Nucleo‐δ‐peptide Analogue
- Peptide Nucleic Acid Probes for Sequence-Specific DNA Biosensors
- Quantitative Monitoring of Gene Expression Patterns with a Complementary DNA Microarray
- Development of a Novel Electrochemical Biosensor for Detection and Discrimination of DNA Sequence and Single Base Mutation in dsDNA Samples Based on PNA-dsDNA Hybridization – a new Platform Technology
- Electrochemical detection of short sequences of hepatitis C 3a virus using a peptide nucleic acid-assembled gold electrode.
- Effect of base mismatch on the electronic properties of DNA-DNA and LNA-DNA double strands: Density-functional theoretical calculations.
Cited by
- Cellulose based genoassays for the detection of pathogen DNA
- Immobilization-free electrochemical DNA detection with anthraquinone-labeled pyrrolidinyl peptide nucleic acid probe.
- A review: fabrications, detections and applications of peptide nucleic acids (PNAs) microarray.
- Detection of bacterial 16S rRNA using a molecular beacon-based X sensor
- A regular thymine tetrad and a peculiar supramolecular assembly in the first crystal structure of an all-LNA G-quadruplex.
- Rapid access with diversity to enantiopure flexible PNA monomers following asymmetric orthogonal strategies
- Optical sensing: recognition elements and devices
- Simple and fast electrochemical detection of sequence-specific DNA via click chemistry-mediated labeling of hairpin DNA probes with ethynylferrocene.
- Versatile design and synthesis platform for visualizing genomes with Oligopaint FISH probes
- Bias in topoisomerase (TOPO)-cloning of multitemplate PCR products using locked nucleic acid (LNA)-substituted primers.
- Novel biosensing methodologies for improving the detection of single nucleotide polymorphism.
- Protected DNA strand displacement for enhanced single nucleotide discrimination in double-stranded DNA
- In Situ Synthesis of Peptide Nucleic Acids in Porous Silicon for Drug Delivery and Biosensing
- The effect of LNA nucleobases as enhancers for the binding of amiloride to an abasic site in DNA/DNA and DNA/RNA duplexes.
- Antisense peptide nucleic acid-functionalized cationic nanocomplex for in vivo mRNA detection
- On-chip detection of a single nucleotide polymorphism without polymerase amplification
- Molecular Beacons of Xeno-Nucleic Acid for Detecting Nucleic Acid
- Paramagnetic Particles and PNA Probe for Automated Separation and Electrochemical Detection of Influenza
- Effects of Variations in Ligand Density on Cell Signaling.
- Insights on chiral, backbone modified peptide nucleic acids: Properties and biological activity
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