Neonatal guanethidine sympathectomy suppresses autotomy and prevents changes in spinal and supraspinal monoamine levels induced by peripheral deafferentation in rats
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Summary
This study supports the hypothesis that the local noradrenaline outflow from sympathetic fibers in the neuroma is one of the causal factors in autotomy and indicates that autotomy is under the control of descending monoaminergic pathways originating in brain‐stem nuclei.
- Type
- article
- Published
- 1994-01-01
- Cited by
- 18
- References
- 34
- Access
- Open access
- OpenAlex
- https://openalex.org/W7512708
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:12876914
Keywords
Marketing, Self-image, Social marketing, Psychology, Sociology
References
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- Behavioral and electrophysiological effects of various types of peripheral nerve lesions in the rat: A comparison of possible models for chronic pain
- Autotomy after nerve sections in the rat is influenced by tonic descending inhibition from locus coeruleus.
- Ongoing activity in severed nerves: source and variation with time.
- Procedures which increase acute pain sensitivity also increase autotomy.
- Studies in autotomy: its pathophysiology and usefulness as a model of chronic pain
- Effects of peripheral antisympathetic treatments in the tail‐flick, formalin and autotomy tests
- Ongoing activity in peripheral nerves: the physiology and pharmacology of impulses originating from a neuroma.
- Deafferentation in animals as a model for the study of pain: an alternative hypothesis
- The production and prevention of experimental anesthesia dolorosa
- The possible participation of a dopaminergic system in mutilating behavior in rats with forelimb deafferentation.
- Modification and characterization of the permanent sympathectomy produced by the administration of guanethidine to newborn rats.
- Autotomy following peripheral nerve lesions: experimental anesthesia dolorosa
- Effects of selective neurotoxic lesion of lumbosacral serotonergic and noradrenergic systems on autotomy behaviour in rats
- Effects of prior anaesthesia on autotomy following sciatic transection in rats
- Neuroma pain model: Correlation of motor behavior and body weight with autotomy in rats
- Changes of reflexes in vasoconstrictor neurons supplying the cat hindlimb following chronic nerve lesions: a model for studying mechanisms of reflex sympathetic dystrophy?
- Autotomy following limb denervation: Effects of previous exposure to neurectomy
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- Formalin-induced nociception activates a monoaminergic descending inhibitory system.
- Antinociceptive effect of clomipramine in monoarthritic rats as revealed by the paw pressure test and the C-fiber-evoked reflex.
- Effect of sodium hydroxybutyrate in pain syndromes
- Reduced basal release of serotonin from the ventrobasal thalamus of the rat in a model of neuropathic pain
- Roles of monoaminergic, glycinergic and GABAergic inhibitory systems in the spinal cord in rats with peripheral mononeuropathy.
- The effects of picric acid (2,4,6-trinitrophenol) and a bite-deterrent chemical (denatonium benzoate) on autotomy in rats after peripheral nerve lesion
- Subtype-specific changes in 5-HT receptor-mediated modulation of C fibre-evoked spinal field potentials are triggered by peripheral nerve injury.
- The &agr;2A adrenoceptor and the sympathetic postganglionic neuron contribute to the development of neuropathic heat hyperalgesia in mice
- Correlation between autotomy-behavior and current theories of neuropathic pain.
- Effects of neurotropin on pain syndromes of various etiology
- Extracellular Levels of 5HT and 5HIAA Increase after an Inflammatory Process in the Rat’s Insular Cortex
- Wirkung von Botulinumtoxin Typ B auf Stumpfschwitzen und Stumpfschmerzen Besteht die Chance der indirekten Phantomschmerzreduktion durch bessere Prothesennutzung
- Disrupted Balance of Short- and Long-Range Functional Connectivity Density in Patients with Herpes Zoster or Postherpetic Neuralgia: A Resting-State fMRI Study
- The Role of the Insular Cortex and Serotonergic System in the Modulation of Long-Lasting Nociception
- THE ROLE OF THE SYMPATHETIC NERVOUS SYSTEM IN PHANTOM LIMB PAIN