Progesterone receptor regulation in uterine cells: stimulation by estrogen, cyclic adenosine 3',5'-monophosphate, and insulin-like growth factor I and suppression by antiestrogens and protein kinase inhibitors.
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Summary
Primary uterine cell cultures were used to study multifactor regulation of progesterone receptor (PR) and the signal transduction pathways which may serve to mediate that regulation and identify cAMP, as well as estrogen and IGF-I, as important regulators of the level of PR in uterine cells.
- Type
- article
- Published
- 1991-04-01
- Cited by
- 205
- References
- 37
- OpenAlex
- https://openalex.org/W2003347015
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25879470
Keywords
Internal medicine, Endocrinology, Adenosine, Estrogen, Cholera toxin
References
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- Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C.
- A simple, rapid, and sensitive DNA assay procedure.
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- Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene
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- Multihormonal regulation of the progesterone receptor in MCF-7 human breast cancer cells: interrelationships among insulin/insulin-like growth factor-I, serum, and estrogen.
- Glucocorticoids and cyclic AMP synergistically regulate the abundance of preproenkephalin messenger RNA in neuroblastoma-glioma hybrid cells.
- Androgen-uterine interactions: an assessment of androgen interaction with the testosterone- and estrogen-receptor systems and stimulation of uterine growth and progesterone-receptor synthesis.
- Complete amino acid sequence of the human progesterone receptor deduced from cloned cDNA.
- Ligand-modulated regulation of progesterone receptor messenger ribonucleic acid and protein in human breast cancer cell lines.
- Identification of a cyclic-AMP-responsive element within the rat somatostatin gene.
- Regulation of progesterone receptor messenger ribonucleic acid and protein levels in MCF-7 cells by estradiol: analysis of estrogen's effect on progesterone receptor synthesis and degradation.
Cited by
- Cloning of the rat progesterone receptor gene 5'-region and identification of two functionally distinct promoters.
- Constitutively active human estrogen receptors containing amino acid substitutions for tyrosine 537 in the receptor protein.
- Regulation of Progesterone Receptors and Decidualization in Uterine Stroma of the Estrogen Receptor-α Knockout Mouse1
- The Scaffolding Protein RACK1 Interacts with Androgen Receptor and Promotes Cross-talk through a Protein Kinase C Signaling Pathway*
- Characterization and regulation of estrogen and progesterone receptors in breast cancer.
- Progesterone receptors in breast cancer.
- Role for oestrogen in dynamic interactions between cell types within the human endometrium
- Effects of low-frequency magnetic fields on implantation in rats.
- Estrogen and raloxifene in experimental arthritis and osteoporosis
- Phosphorylation and steroid hormone action.
- Ligand-independent activation of the androgen receptor by the differentiation agent butyrate in human prostate cancer cells.
- Intracellular signaling pathways: nongenomic actions of estrogens and ligand-independent activation of estrogen receptors.
- New targets for therapy in breast cancer: Mammalian target of rapamycin (mTOR) antagonists
- Pregnancy-dependent to ovarian-independent progression in mammary tumors delineated in primary culture: changes in signal transduction, growth factor regulation, and matrix interaction.
- Sex Steroids and the Brain: Lessons from Animal Studies
- Examination of the DNA-binding ability of estrogen receptor in whole cells: implications for hormone-independent transactivation and the actions of antiestrogens
- Progesterone-dependent regulation of female reproductive activity by two distinct progesterone receptor isoforms.
- Regulation of sex steroid receptor gene expression by progesterone and testosterone in cultured human endometrial stromal cells.
- Interaction of insulin-like growth factor-I and estradiol signaling pathways on hypothalamic neuronal differentiation.
- Critical Review and Evaluation of the Uterotrophic Bioassay for the Identification of Possible Estrogen Agonists and Antagonists: In Support of the Validation of the OECD Uterotrophic Protocols for the Laboratory Rodent
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