Glucocorticoid receptors in the locus coeruleus mediate sleep disorders caused by repeated corticosterone treatment

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Summary

It is suggested that GR in LC may play a key role in stress-related sleep disorders and support the hypothesis that repeated CORT treatment may decrease GR levels and induce the activation of noradrenergic neurons in LC, consequently inhibit GABAergic neuron in VLPO and result in sleep disorders.

Type
article
Published
2015-03-24
Cited by
58
References
67
Access
Open access

Keywords

Locus coeruleus, Corticosterone, Glucocorticoid, Glucocorticoid receptor, Endocrinology

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