Altered GABAergic and glutamatergic activity within the rat hippocampus and amygdala in rats subjected to repeated corticosterone administration but not restraint stress.
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Summary
The findings parallel the previous results showing that repeated CORT injections, but not restraint stress, increase depression-like behavior in rats, and suggest that the depressogenic effects of CORT may be related to alterations in GABAergic and glutamatergic neurotransmission in stress-sensitive regions of the brain.
- Type
- article
- Published
- 2013-02-12
- Cited by
- 58
- References
- 83
- OpenAlex
- https://openalex.org/W1979526507
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:13400055
Keywords
Glutamatergic, Endocrinology, Hippocampus, Corticosterone, Internal medicine
References
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Cited by
- GABAergic control of the activity of the central nucleus of the amygdala in low- and high-anxiety rats.
- Examining Hippocampal Reelin Expression and Neural Plasticity in an Animal Model of Depression
- The neuroenergetics of stress hormones in the hippocampus and implications for memory
- The GAD65 knock out mouse – a model for GABAergic processes in fear‐ and stress‐induced psychopathology
- Changes in the brain expression of alpha-2 subunits of the GABA-A receptor after chronic restraint stress in low- and high-anxiety rats.
- Glutamate and GABA imbalance promotes neuronal apoptosis in hippocampus after stress
- The effect of chronic administration of corticosterone on anxiety- and depression-like behavior and the expression of GABA-A receptor alpha-2 subunits in brain structures of low- and high-anxiety rats.
- Glucocorticoid receptors in the locus coeruleus mediate sleep disorders caused by repeated corticosterone treatment
- Transcriptional Regulation of Glutamic Acid Decarboxylase in the Male Mouse Amygdala by Dietary Phyto‐Oestrogens
- Age-specific transcriptional response to stroke.
- Cholesterol and Perhaps Estradiol Protect Against Corticosterone-Induced Hippocampal CA3 Dendritic Retraction in Gonadectomized Female and Male Rats
- Uwhangchungsimwon, a traditional herbal medicine, protects brain against oxidative injury via modulation of hypothalamus-pituitary-adrenal (HPA) response in a chronic restraint mice model.
- The progressive development of depression-like behavior in corticosterone-treated rats is paralleled by slowed granule cell maturation and decreased reelin expression in the adult dentate gyrus.
- Prenatal ethanol exposure induces an intrauterine programming of enhanced sensitivity of the hypothalamic–pituitary–adrenal axis in female offspring rats fed with post-weaning high-fat diet
- Temporal control of glucocorticoid neurodynamics and its relevance for brain homeostasis, neuropathology and glucocorticoid-based therapeutics.
- Short-term repeated corticosterone administration enhances glutamatergic but not GABAergic transmission in the rat motor cortex
- Reelin Proteolysis Affects Signaling Related to Normal Synapse Function and Neurodegeneration
- Reelin-Related Disturbances in Depression: Implications for Translational Studies
- GABA-BZD Receptor Modulating Mechanism of Panax quinquefolius against 72-h Sleep Deprivation Induced Anxiety like Behavior: Possible Roles of Oxidative Stress, Mitochondrial Dysfunction and Neuroinflammation
- Orbitofrontal Cortex 5-HT1A Receptor Modulate Glutamate and GABA in Depression Induced by Chronic Unpredictable Mild Stress
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