Low Affinity Binding Site Clusters Confer Hox Specificity and Regulatory Robustness
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Summary
It is demonstrated that the Hox protein Ultrabithorax (Ubx) in complex with its cofactor Extradenticle (Exd) bound specifically to clusters of very low affinity sites in enhancers of the shavenbaby gene of Drosophila.
- Type
- article
- Published
- 2014-12-31
- Cited by
- 349
- References
- 73
- Access
- Open access
- OpenAlex
- https://openalex.org/W2002964220
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:2978797
Keywords
Ultrabithorax, Hox gene, Biology, Enhancer, Transcription factor
References
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- Low-affinity transcription factor binding sites shape morphogen responses and enhancer evolution
- Hox Specificity: Unique Roles for Cofactors and Collaborators
- ovo/svb integrates Wingless and DER pathways to control epidermis differentiation
- Cloning of the homeotic Sex combs reduced gene in Drosophila and in situ localization of its transcripts
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- Morphological evolution through multiple cis-regulatory mutations at a single gene
- Molecular integration of wingless, decapentaplegic, and autoregulatory inputs into Distalless during Drosophila leg development.
- Phenotypic robustness conferred by apparently redundant transcriptional enhancers
- Common functions of central and posterior Hox genes for the repression of head in the trunk of Drosophila
- Predicting expression patterns from regulatory sequence in Drosophila segmentation
- Binding affinities and cooperative interactions with bHLH activators delimit threshold responses to the dorsal gradient morphogen.
- Functional dissection of Ultrabithorax proteins in D. melanogaster.
- Nuclear translocation of extradenticle requires homothorax, which encodes an extradenticle-related homeodomain protein.
- The Ovo/Shavenbaby transcription factor specifies actin remodelling during epidermal differentiation in Drosophila.
- Genes controlling segmental specification in the Drosophila thorax.
- A gene complex controlling segmentation in Drosophila
- Homeobox genes and axial patterning.
- The role of DNA shape in protein-DNA recognition
- Determination of spatial domains of zygotic gene expression in the Drosophila embryo by the affinity of binding sites for the bicoid morphogen
Cited by
- Transcriptional Responses to the Auxin Hormone.
- An ancient yet flexible cis-regulatory architecture allows localized Hedgehog tuning by patched/Ptch1
- In silico evolution of the Drosophila gap gene regulatory sequence under elevated mutational pressure
- Degenerate Pax2 and Senseless binding motifs improve detection of low-affinity sites required for enhancer specificity
- Chromatin accessibility plays a key role in selective targeting of Hox proteins
- Intersecting transcription networks constrain gene regulatory evolution
- Pervasive robustness in biological systems
- Probing the kinetic landscape of Hox transcription factor-DNA binding in live cells by massively parallel Fluorescence Correlation Spectroscopy.
- BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis
- Cellular and molecular insights into Hox protein action
- Toward a new twist in Hox and TALE DNA-binding specificity.
- GATA1 directly mediates interactions with closely spaced pseudopalindromic but not distantly spaced double GATA sites on DNA
- Deconvolving the recognition of DNA shape from sequence
- Homeodomain proteins: an update
- A widespread role of the motif environment in transcription factor binding across diverse protein families
- Cis-Regulatory Mechanisms for Robust Olfactory Sensory Neuron Class-restricted Odorant Receptor Gene Expression in Drosophila
- Hox genes, evo-devo, and the case of the ftz gene
- Gene Regulatory Mechanisms Underlying the Spatial and Temporal Regulation of Target-Dependent Gene Expression in Drosophila Neurons
- Hox proteins act as transcriptional guarantors to ensure terminal differentiation
- Quantitatively predictable control of Drosophila transcriptional enhancers in vivo with engineered transcription factors
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