Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection
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Summary
A mathematical model of random viral evolution and phylogenetic tree construction is developed and used to analyze 3,449 complete env sequences derived by single genome amplification from 102 subjects with acute HIV-1 (clade B) infection, suggesting a finite window of potential vulnerability of HIV- 1 to vaccine-elicited immune responses, although phenotypic properties of transmitted Envs pose a formidable defense.
- Type
- article
- Published
- 2008-05-27
- Cited by
- 2,000
- References
- 32
- Access
- Open access
- OpenAlex
- https://openalex.org/W2002574877
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11321908
Keywords
Biology, Virology, Phylogenetic tree, Viral evolution, Viremia
References
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- DNA recombination during PCR.
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- Gender differences in HIV-1 diversity at time of infection
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- Incidence of HIV-1 dual infection and its association with increased viral load set point in a cohort of HIV-1 subtype C-infected female sex workers.
- A Novel Antiviral Intervention Results in More Accurate Assessment of Human Immunodeficiency Virus Type 1 Replication Dynamics and T-Cell Decay In Vivo
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Cited by
- Detection of quasispecies variants predicted to use CXCR4 by ultra-deep pyrosequencing during early HIV infection
- The Development of an AIDS Mucosal Vaccine
- HIV vaccines: an attainable goal?
- HIV transmission.
- Transmitted/Founder and Chronic HIV-1 Envelope Proteins Are Distinguished by Differential Utilization of CCR5
- Longitudinal Ultradeep Characterization of HIV Type 1 R5 and X4 Subpopulations in Patients Followed from Primary Infection to Coreceptor Switch
- Postintegration HIV-1 infection of cervical epithelial cells mediates contact-dependent productive infection of T cells.
- A Twin-Cysteine Motif in the V2 Region of gp120 Is Associated with SIV Envelope Trimer Stabilization
- A combination HIV reporter virus system for measuring post-entry event efficiency and viral outcome in primary CD4+ T cell subsets
- HIV Vaccines
- Calcitonin gene‐related peptide inhibits human immunodeficiency type 1 transmission by Langerhans cells via an autocrine/paracrine feedback mechanism
- Neutralisation of HIV-1 cell-cell spread by human and llama antibodies
- The Combination of Phylogenetic Analysis with Epidemiological and Serological Data to Track HIV-1 Transmission in a Sexual Transmission Case
- HLA Class-II Associated HIV Polymorphisms Predict Escape from CD4+ T Cell Responses
- Guidelines for cloning, expression, purification and functional characterization of primary HIV-1 envelope glycoproteins.
- Natural infection as a blueprint for rational HIV vaccine design
- Survivors Remorse: antibody-mediated protection against HIV-1
- Complex Immune Correlates of Protection in HIV-1 Vaccine Efficacy Trials
- Disparate impact on CD4 T cell count by two distinct HIV-1 phylogenetic clusters from the same clade
- The Ontogeny of Mucosal and Systemic Antibody Responses to HIV-1 Infection
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