Biomechanical signals inhibit IKK activity to attenuate NF-kappaB transcription activity in inflamed chondrocytes.
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Summary
Results indicate that the signals generated by cyclic tensile strain act at multiple sites within the NF-kappaB signaling cascade to inhibit IL-1beta-induced proinflammatory gene induction, which provides insight into how biomechanical signals regulate and reduce inflammation.
- Type
- article
- Published
- 2007-10-01
- Cited by
- 70
- References
- 56
- Access
- Open access
- OpenAlex
- https://openalex.org/W2002250615
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23816039
Keywords
Transactivation, Proinflammatory cytokine, IκB kinase, NF-κB, IκBα
References
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- A cytokine-responsive IκB kinase that activates the transcription factor NF-κB
- Biomechanical Strategies for Articular Cartilage Regeneration
- Cytokines in cartilage injury and repair.
- Inhibition of NF-kappa B by sodium salicylate and aspirin.
- Effect of stretching on gene expression of beta1 integrin and focal adhesion kinase and on chondrogenesis through cell-extracellular matrix interactions.
- Integrin-interleukin-4 mechanotransduction pathways in human chondrocytes.
- Constitutive and interleukin-1-inducible phosphorylation of p65 NF-kappaB at serine 536 is mediated by multiple protein kinases including IkappaB kinase (IKK)-alpha, IKKbeta, IKKepsilon, TRAF family member-associated (TANK)-binding kinase 1 (TBK1), and an unknown kinase and couples p65 to
- INTEGRINS AND STRETCH ACTIVATED ION CHANNELS; PUTATIVE COMPONENTS OF FUNCTIONAL CELL SURFACE MECHANORECEPTORS IN ARTICULAR CHONDROCYTES
- Positive effects of moderate exercise on glycosaminoglycan content in knee cartilage: a four-month, randomized, controlled trial in patients at risk of osteoarthritis.
- Animal models of rheumatoid arthritis.
- Interleukin-1 (IL-1)-induced TAK1-dependent Versus MEKK3-dependent NFκB Activation Pathways Bifurcate at IL-1 Receptor-associated Kinase Modification*
- The TNF-α transgenic mouse model of inflammatory arthritis
Cited by
- Sports, loading of cartilage, osteoarthritis and its prevention
- Synovial and mucosal immunopathology in spondyloarthritis.
- Mechanosignaling in Bone Health, Trauma and Inflammation
- A Model System of the Dynamic Loading Occurring in Synovial Joints: The Biological Effect of Plowing on Pristine Cartilage
- Mechanotransduction and cartilage integrity
- Mechanical Intervention for Maintenance of Cartilage and Bone
- Extracellular matrix integrity affects the mechanical behaviour of in-situ chondrocytes under compression.
- [Pathophysiology of osteoarthritis: updated concepts].
- Biomechanical Thresholds Regulate Inflammation through the NF-κB Pathway: Experiments and Modeling
- Mechanical Loading of Articular Cartilage Reduces IL-1-Induced Enzyme Expression
- Mechanical loading, cartilage degradation, and arthritis
- Cyclic mechanical stretch downregulates IL-1β-induced COX-2 expression and PGE2 production in rheumatoid arthritis fibroblast-like synoviocytes
- Regulation of chondrocytic gene expression by biomechanical signals.
- Effects of Cyclic Tensile Strain on Chondrocyte Metabolism: A Systematic Review
- Homeostatic Mechanisms in Articular Cartilage and Role of Inflammation in Osteoarthritis
- The Basic Science of Continuous Passive Motion in Promoting Knee Health: A Systematic Review of Studies in a Rabbit Model
- Role of miR-146a in human chondrocyte apoptosis in response to mechanical pressure injury in vitro
- Stretching of the Back Improves Gait, Mechanical Sensitivity and Connective Tissue Inflammation in a Rodent Model
- Mechanical Loading: Bone Remodeling and Cartilage Maintenance
- Biomechanical factors in osteoarthritis
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