Reduced T-Cell and Dendritic Cell Function Is Related to Cyclooxygenase-2 Overexpression and Prostaglandin E2 Secretion in Patients With Breast Cancer
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Summary
COx-2–induced PGE2 may contribute to immunosuppression and may directly block antitumor immunity while promoting tumor growth, providing the rationale for using COX-2 inhibition combined with immunotherapy.
- Type
- article
- Published
- 2004-03-01
- Cited by
- 181
- References
- 50
- OpenAlex
- https://openalex.org/W2002235017
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:12107328
Keywords
Medicine, Immune system, Prostaglandin E2, Breast cancer, Immunology
References
- Regulation of immune responses by TGF-beta.
- Inhibition of the differentiation of dendritic cells from CD34(+) progenitors by tumor cells: role of interleukin-6 and macrophage colony-stimulating factor.
- Suppressed T-cell receptor zeta chain expression and cytokine production in pancreatic cancer patients.
- Loss of T-cell receptor zeta chain and p56lck in T-cells infiltrating human renal cell carcinoma.
- An assessment of the immunological status of patients with renal cell carcinoma based on the relative abundance of T‐helper 1‐ and ‐2 cytokine‐producing CD4+ cells in peripheral blood
- Decreased antigen presentation by dendritic cells in patients with breast cancer.
- Prostaglandin E2 differentially modulates cytokine secretion profiles of human T helper lymphocytes.
- Cyclooxygenase-2 expression in human breast cancers and adjacent ductal carcinoma in situ.
- G-Protein-coupled receptors: Lipidated peptides: a therapeutic tool kit
- Induction of antigen-specific T cell anergy: An early event in the course of tumor progression.
- Immunologic Monitoring of Cancer Vaccine Therapy: Results of a Workshop Sponsored by the Society for Biological Therapy
- Effects of prostaglandin E(2) on proliferation and apoptosis of epithelial ovarian cancer cells.
- Enzyme immunoassays of eicosanoids using acetylcholine esterase as label: an alternative to radioimmunoassay.
- Prostaglandin E(2) is a selective inducer of interleukin-12 p40 (IL-12p40) production and an inhibitor of bioactive IL-12p70 heterodimer.
- Regulation of prostaglandin synthase-1 and prostaglandin synthase-2
- Where have all the T cells gone? Mechanisms of immune evasion by tumors.
- Analysis of Th1 and Th2 cytokine production by peripheral blood mononuclear cells as a parameter of immunological dysfunction in advanced cancer patients
- Induction of antitumor immunity by indomethacin
- Prostaglandin synthase 2.
- PBLs of early breast carcinoma patients with a high nuclear grade tumor unlike PBLs of cervical carcinoma patients do not show a decreased TCR zeta expression but are functionally impaired.
Cited by
- Basic Science Review: Nitric Oxide—Releasing Prosthetic Materials
- Suppressive Influences in the Immune Response to Cancer
- Prostaglandin E2 prevents Helicobacter-induced gastric preneoplasia and facilitates persistent infection in a mouse model.
- Regulation of COX2 Expression in Mouse Mammary Tumor Cells Controls Bone Metastasis and PGE2-Induction of Regulatory T Cell Migration
- Antitumor activity of celecoxib, a selective cyclooxygenase-2 inhibitor, in medullary thyroid carcinoma.
- [The anti-tumor immune response in breast cancer: Update and therapeutic perspectives].
- Secretion of VEGF by oral squamous cell carcinoma cells skews endothelial cells to suppress T-cell functions
- Targeting cyclooxygenase-2 for cancer prevention and treatment.
- Effect of celecoxib combined with chemotherapy drug on malignant biological behaviors of gastric cancer.
- Combination of physical activity, nutrition, or other metabolic factors and vaccine response.
- Cyclooxygenase-2 (cox-2) and the inflammogenesis of cancer.
- Dendritic cell-based immunotherapy: A promising approach for treatment of cancer
- Caractérisation de l'activité fonctionnelle et métabolique des cellules NK en situation de stress nutritionnels : approche expérimentale in vitro et in vivo
- COX-derived prostanoid pathways in gastrointestinal cancer development and progression: novel targets for prevention and intervention.
- The novel use of recombinant granulocyte-macrophage colony stimulating factor (GM-CSF) to reverse cerebral amyloidosis and cognitive impairment in Alzheimer's disease mouse models: Insights from the investigation of Rheumatoid arthritis as a negative risk factor for Alzheimer's disease
- PHENOTYPE AND POLARIZATION OF AUTOLOGOUS T CELLS BY BIOMATERIAL-TREATED DENDRITIC CELLS
- Mechanisms underlying the growth inhibitory effects of the cyclo-oxygenase-2 inhibitor celecoxib in human breast cancer cells
- Cyclooxygenase-2 Inhibitor Enhances the Efficacy of a Breast Cancer Vaccine: Role of IDO1
- Propofol inhibits cyclo-oxygenase activity in human monocytic THP-1 cells
- In vitro-Evaluation kombinierter immunologischer und pharmakologischer Therapiestrategien zur Behandlung des Pankreaskarzinoms
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